Please use this identifier to cite or link to this item:
Title: Induction of protective immunity in a Syrian hamster model against a cytopathogenic strain of Andes virus
Authors: Martínez, Valeria Paula 
Padula, Paula 
Issue Date: 2012
Description: Andes virus (ANDV) is responsible for the Hantavirus Pulmonary Syndrome cases in Argentina and neighboring countries, with moderate to high case-fatality rates. ANDV has some particular features, which make it unique among other members of the Hantavirus genus such as person-to-person transmission and causing a disease similar to Hantavirus Pulmonary Syndrome in the hamster as an animal model. The kinetics of replication in Vero E6 cells of an ANDV strain isolated in Argentina, called Andes/ARG, was studied. Cytopathic effect and the formation of clear plaques were observed and therefore Andes/ARG could be quantified by classic plaque assay. The Andes/ ARG strain was found to be highly lethal in Syrian hamsters allowing experiments to demonstrate the protective potential of vaccines. A recombinant nucleocapsid protein of ANDV induced a long lasting antibody response and protective immunity against a homologous challenge, but to a lower extent against heterologous challenge by the Seoul virus.
Rights: restrictedAccess
Appears in Collections:Publicaciones INEI

Files in This Item:
File Description SizeFormat
JournalofMedicalVirology 84,87–95,2012.pdfPDF266.8 kBAdobe PDFThumbnail
Show full item record

Page view(s)

checked on Nov 12, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.