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Title: | Induction of protective immunity in a Syrian hamster model against a cytopathogenic strain of Andes virus | Authors: | Martínez, Valeria Paula Padula, Paula |
Issue Date: | Jan-2012 | Abstract: | Andes virus (ANDV) is responsible for the Hantavirus Pulmonary Syndrome cases in Argentina and neighboring countries, with moderate to high case-fatality rates. ANDV has some particular features, which make it unique among other members of the Hantavirus genus such as person-to-person transmission and causing a disease similar to Hantavirus Pulmonary Syndrome in the hamster as an animal model. The kinetics of replication in Vero E6 cells of an ANDV strain isolated in Argentina, called Andes/ARG, was studied. Cytopathic effect and the formation of clear plaques were observed and therefore Andes/ARG could be quantified by classic plaque assay. The Andes/ ARG strain was found to be highly lethal in Syrian hamsters allowing experiments to demonstrate the protective potential of vaccines. A recombinant nucleocapsid protein of ANDV induced a long lasting antibody response and protective immunity against a homologous challenge, but to a lower extent against heterologous challenge by the Seoul virus. |
Description: | Fil: Martínez, Valeria Paula. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Laboratorio de Hantavirus; Argentina. Fil: Padula, Paula Julieta. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Laboratorio de Hantavirus; Argentina. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/446 | Rights: | Closed Access |
Appears in Collections: | Preproducción Publicaciones INEI |
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