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|Title:||Induction of protective immunity in a Syrian hamster model against a cytopathogenic strain of Andes virus||Authors:||Martinez, Valeria Paula
|Issue Date:||2012||Description:||Andes virus (ANDV) is responsible for the Hantavirus Pulmonary Syndrome cases in Argentina and neighboring countries, with moderate to high case-fatality rates. ANDV has some particular features, which make it unique among other members of the Hantavirus genus such as person-to-person transmission and causing a disease similar to Hantavirus Pulmonary Syndrome in the hamster as an animal model. The kinetics of replication in Vero E6 cells of an ANDV strain isolated in Argentina, called Andes/ARG, was studied. Cytopathic effect and the formation of clear plaques were observed and therefore Andes/ARG could be quantified by classic plaque assay. The Andes/ ARG strain was found to be highly lethal in Syrian hamsters allowing experiments to demonstrate the protective potential of vaccines. A recombinant nucleocapsid protein of ANDV induced a long lasting antibody response and protective immunity against a homologous challenge, but to a lower extent against heterologous challenge by the Seoul virus.||URI:||http://sgc.anlis.gob.ar/handle/123456789/446||Rights:||restrictedAccess|
|Appears in Collections:||Publicaciones INEI|
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|JournalofMedicalVirology 84,87–95,2012.pdf||266.8 kB||Adobe PDF|
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