Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/433
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dc.contributor.authorde Oliveira, Vanessa Costaes
dc.contributor.authorLanari, Laura Ceciliaes
dc.contributor.authorHajos, Silvia Elviraes
dc.contributor.authorde Roodt, Adolfo R.es
dc.date.accessioned2012-12-06T00:51:52Z-
dc.date.available2012-12-06T00:51:52Z-
dc.date.issued2011-04-
dc.identifier.issn0041-0101-
dc.identifier.urihttp://sgc.anlis.gob.ar/handle/123456789/433-
dc.identifier.urihttps://doi.org/10.1016/j.toxicon.2011.01.012-
dc.descriptionFil: de Oliveira, Vanessa Costa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.es
dc.descriptionFil: Lanari, Laura Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.es
dc.descriptionFil: Hajos, Silvia Elvira. Universidad de Buenos Aires. Cátedra de Imunología; Argentina.es
dc.descriptionFil: de Roodt, Adolfo R. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.es
dc.description.abstractWe report a study of toxic and enzymatic activities of Bothrops neuwiedi complex venoms collected from specimens of different regions of Argentina and a pool of these same venoms. Were determined lethal, hemorrhagic and pro-coagulant (plasma and fibrinogen) doses and the neutralization of these activities by a bivalent antivenom. The electrophoretic pattern of different regions venom was studied by SDS–PAGE. All samples exhibited lethal potencies, hemorrhagic and coagulant (plasma and fibrinogen) activities with potencies concordant with previous studies. The only conspicuous difference in the toxicological pattern of Bothrops diporus venoms was the low-thrombin-like activity found in one sample. The antivenom used in this study could neutralize all the toxic activities tested and the neutralizing potency of the antivenom was comparable for all samples. Despite the wide distribution of B. neuwiedi complex throughout Argentina and the evident morphological variation between B. diporus (B. neuwiedi complex), this study establishes a remarkably similar toxicity profile throughout its range. This is the first systematic study on the regional variation of enzymatic and toxic activities of venom from species belonging to the B. neuwiedi complex, one of the snakes of highest sanitary importance in South America and their neutralization by the type of antivenom most commonly used in the South of South America.es
dc.formatapplication/pdfES
dc.language.isoenes
dc.publisherElsevieres
dc.relation.ispartofToxicones
dc.rightsinfo:eu-repo/semantics/closedaccessen_US
dc.sourceToxicon 2011; 57(5): 680-685.en_US
dc.subjectBothropses
dc.subjectVenenos de Serpientees
dc.subjectAntivenenoses
dc.subjectArgentinaes
dc.titleToxicity of Bothrops neuwiedi complex (“yarará chica”) venom from different regions of Argentina (Serpentes, Viperidae)es
dc.typeArtículoes
dc.coverageARGen_US
anlis.essnrd1es
item.openairetypeArtículo-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.deptInstituto Nacional de Producción de Biológicos (INPB)-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
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