Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/426
Title: Circulating Epstein-Barr virus (EBV) in HIV-infected patients and its relation with primary brain lymphoma
Authors: Fellner, María Dolores 
Durand, Karina 
Correa, Rita Mariel 
Redini, Liliana 
Yampolsky, Claudio 
Colobraro, Antonio 
Sevlever, Gustavo 
Teyssie, Angelica R. 
Benetucci, Jorge 
Picconi, María Alejandra 
Keywords: Herpesvirus Humano 4;VIH;Linfoma
Issue Date: 2007
Description: OBJECTIVE To analyze Epstein-Barr virus (EBV) load at different HIV infection stages and its relation with brain lymphoma. DESIGN A cross-sectional study was conducted on 172 HIV-infected individuals: 62 asymptomatic HIV carriers (group A), 30 HIV progressors (group B), 73 AIDS patients (group C), seven AIDS patients with brain lymphoma (group C-BL); and 26 blood donors (group BD) as healthy carriers. EBV load was measured in peripheral blood mononuclear cells (PBMC) and plasma samples using a semi-quantitative PCR method. RESULTS PBMC-EBV levels in HIV-infected patients were higher than in the blood donors (p<0.05). No differences in PBMC-EBV loads were found in groups A, B, or C (p>0.05), while the C-BL group had significantly lower levels (p<0.05). Similar PBMC-EBV loads were seen in HIV-infected patients with CD4+ T cell counts higher than 50/mm(3) (p>0.05), while significantly lower levels were found in cases with less than 50 cells/mm(3) (p<0.05). In all HIV-infected patients, plasma-EBV load was lower than, or similar to, PBMC-EBV load, unlike 2/7 HIV-positive brain lymphoma patients. CONCLUSIONS During HIV infection PBMC-EBV load rises in comparison to healthy carriers, but decreases when immunosuppression progresses and CD4+ T cell count becomes <50/mm(3). Circulating EBV is mainly cell-associated in the HIV-infected population. Neither PBMC-EBV nor plasma-EBV loads would be useful to diagnose brain lymphoma in AIDS patients.
Fil: Fellner, María Dolores. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Durand, Karina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Correa, Rita Mariel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Redini, Liliana. FUNDAI. Laboratorio de Retrovirus y Virus asociados; Argentina.
Fil: Yampolsky, Claudio. Sanatorio Guemes. Servicio de Neurocirugía; Argentina.
Fil: Colobraro, Antonio. Instituto FLENI. Servicio de Patología; Argentina.
Fil: Sevlever, Gustavo. Instituto FLENI. Servicio de Patología; Argentina.
Fil: Teyssié, Angélica R. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
Fil: Benetucci, Jorge. FUNDAI. Laboratorio de Retrovirus y Virus asociados; Argentina.
Fil: Picconi, María Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.
URI: http://download.journals.elsevierhealth.com/pdfs/journals/1201-9712/PIIS1201971206000841.pdf
http://sgc.anlis.gob.ar/handle/123456789/426
ISSN: 1201-9712
Rights: 2008-03-31
info:eu-repo/semantics/embargoedAccess
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