Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/384
Title: Characterization of a vaccinia virus strain used to produce smallpox vaccine in Argentina between 1937 and 1970
Authors: Lewis, Adrian P. 
Bok, Karin 
Perez, O. 
DeFillippo, J. 
Paolazzi, C. 
Gomez, Jorge A. 
Keywords: Argentina;Vacuna contra Viruela;Virus Vaccinia;Vacunas Atenuadas;Proteínas del Envoltorio Viral
Issue Date: 2005
Description: Due to recent political developments, smallpox has re-emerged as a serious threat. We recovered and characterized an old batch of smallpox vaccine, Malbrán strain, produced between 1945 and 1949. The virus was re-isolated and characterized by sequence analysis and biological activity in animals. Phylogenetic analysis using the hemagglutinin and A45R genes showed that the Malbrán strain was closely related to the Lister strain of vaccinia virus. In animals, the Malbrán strain exhibited low pathogenicity, confirming historical records. Mice immunized with the Malbrán strain survived a lethal challenge with cowpox virus. Thus, this strain of vaccinia virus remains a viable candidate as a smallpox vaccine.
Fil: Lewis, Adrian P. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.
Fil: Bok, Karin. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.
Fil: Perez, O. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.
Fil: DeFillippo, J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.
Fil: Paolazzi, C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.
Fil: Gomez, Jorge A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología; Argentina.
URI: http://sgc.anlis.gob.ar/handle/123456789/384
http://link.springer.com/article/10.1007%2Fs00705-005-0498-9
ISSN: 1432-8798
Rights: info:eu-repo/semantics/restrictedAccess
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