Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/368
Title: In vitro susceptibility studies of Cryptococcus neoformans isolated from patients with no clinical response to amphotericin B therapy
Authors: Rodero, Laura 
Córdoba, Susana 
Cahn, Pedro 
Hochenfellner, F. 
Davel, Graciela 
Canteros, C. E. 
Kaufman, Sara 
Guelfand, Liliana 
Keywords: Anfotericina B;Cryptococcus neoformans;Humanos;Farmacorresistencia Microbiana
Issue Date: 2000
Description: The in vitro activities of three antifungal drugs alone and in combination were evaluated against five isolates of Cryptococcus neoformans using time-kill curves (TKC). The isolates were from AIDS patients who had either died or had failed to show a clinical response during amphotericin B (AMB) treatment. AMB, fluconazole (FCZ) and flucytosine (5FC), and combinations of the drugs (AMB plus 5FC, AMB plus rifampicin (RIF) and FCZ plus 5FC), were evaluated. With all five isolates AMB did not show fungicidal activity; instead, a persistent or tolerant effect was observed. Combinations of AMB plus 5FC and AMB plus RIF showed a clear synergic effect, except for one isolate tested with AMB plus RIF. In contrast, the FCZ plus 5FC combination did not inhibit growth of any isolate.
Fil: Rodero, Laura. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Córdoba, Susana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Cahn, Pedro. Hospital J. A. Fernadez; Argentina.
Fil: Hochenfellner, F. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Davel, Graciela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Canteros, C. E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
Fil: Kaufman, Sara. Hospital J. A. Fernadez; Argentina.
Fil: Guelfand, Liliana. Hospital J. A. Fernadez; Argentina.
URI: http://jac.oxfordjournals.org/content/45/2/239.full.pdf+html
http://sgc.anlis.gob.ar/handle/123456789/368
ISSN: 1460-2091
Rights: info:eu-repo/semantics/embargoedAccess
2001-02-01
Appears in Collections:Publicaciones INEI
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