Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/363
Title: Deletion of the Correia element in the mtr gene complex of Neisseria meningitidis
Authors: Enríquez, Rocío 
Abad, Raquel 
Chanto, Grettel 
Corso, Alejandra 
Cruces, Raquel 
Gabastou, Jean-Marc 
Gorla, María Cecilia 
Maldonado, Aurora 
Moreno, Jaime 
Muros-Le Rouzic, Erwan 
Sorhouet Pereira, Cecilia 
Vázquez, Julio A. 
Keywords: Neisseria meningitidis
Issue Date: 2010
Description: The mtr gene complex in Neisseria meningitidis encodes an efflux pump that is responsible for export of antibacterial hydrophobic agents. The promoter region of the mtrCDE operon harbours an insertion sequence known as a Correia element, and a binding site for the integration host factor (IHF) is present at the centre of the Correia element. It has been suggested that the expression of the mtrCDE operon in meningococci is subject to transcriptional regulation by the IHF and post-transcriptional regulation by cleavage in the inverted repeat of the Correia element. The promoter region of the mtrCDE operon as well as the association of changes at that point with decreased susceptibility to antimicrobial drugs in 606 Neisseria meningitidis strains were analysed in this study. Two different deletions were present in the analysed region. The first one, found in seven strains, corresponded to absence of the Correia element. The second one, affecting the -10 region and first 100 bp of the mtrR gene and present in 57 isolates, was only found in ST-1624 isolates. None of the deletions were associated with decreased susceptibility to antimicrobial drugs. Although most of the meningococcal strains carry the Correia element at that position, its deletion is not an exception.
Fil: Enríquez, Rocío. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.
Fil: Abad, Raquel. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.
Fil: Chanto, Grettel. Centro Nacional de Referencia en Bacteriología (INCIENSA); Costa Rica.
Fil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Bacteriología; Argentina.
Fil: Cruces, Raquel. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.
Fil: Marc Gabastou, Jean. Pan American Health Organization (PAHO). Unidad de Medicamentos Esenciales; Ecuador.
Fil: Gorla, María Cecilia. Adolfo Lutz Institute. Bacteriology Branch. Brasil.
Fil: Maldonado, Aurora. Instituto de Salud Pública (ISP). Bacteriología; Chile.
Fil: Moreno, Jaime. Instituto Nacional de Salud (INS). Microbiología. Colombia.
Fil: Muros-Le Rouzic, Erwan. Sanofi-Pasteur. Global Scientific & Medical Affairs; Francia.
Fil: Sorhouet, Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Bacteriología; Argentina.
Fil: Vazquez, Julio A. Instituto de Salud Carlos III. Laboratorio de Referencia para meningococos; España.
URI: http://jmm.sgmjournals.org/content/59/9/1055.full.pdf
http://sgc.anlis.gob.ar/handle/123456789/363
ISSN: 0022-2615
Rights: 2011-09-30
info:eu-repo/semantics/embargoedAccess
Appears in Collections:Publicaciones INEI
snrd

Files in This Item:
File Description SizeFormat
JournalofMedicalMicrobiology,2010,59(9),1055–1060.pdfPDF220.21 kBAdobe PDFThumbnail
View/Open
Show full item record

Page view(s)

4
checked on Nov 13, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.