Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/279
Title: Evolution of an International External Quality Assurance Model To Support Laboratory Investigation of Streptococcus pneumoniae, Developed for the SIREVA Project in Latin America, from 1993 to 2005
Authors: Lovgren, Marguerite 
Talbot, James A. 
Brandileone, Maria Cristina 
Casagrande, Silvana T. 
Agudelo, Clara Inés 
Castañeda, Elizabeth 
Regueira, Mabel 
Corso, Alejandra 
Heitmann, Ingrid 
Maldonado, Aurora 
Echániz-Avilés, Gabriela 
Soto-Noguerón, Araceli 
Hortal, María 
Camou, Teresa 
Gabastou, Jean-Marc 
Fabio, José Luis Di 
Grupo SIREVA 
Keywords: Control de Calidad;Streptococcus pneumoniae;Estudios Prospectivos;Laboratorios;Pruebas de Sensibilidad Microbiana;Oxacilina
Issue Date: 2007
Description: In 1993 the Pan American Health Organization initiated a laboratory-based surveillance system, called the SIREVA project, to learn about Streptococcus pneumoniae invasive disease in Latin American children. In 1994, National Laboratories in six countries were trained to perform serotyping and antibiotic susceptibility testing using broth microdilution to determine the MIC for specified antibiotics. An international External Quality Assurance (EQA) program was developed to monitor and support ongoing laboratory performance. The EQA program was coordinated by the National Centre for Streptococcus (NCS), Edmonton, Canada, and included external proficiency testing (EPT) and a validation process requiring regular submission of a sample of isolates from each laboratory to the NCS for verification of the serotype and MIC. In 1999, the EQA program was decentralized to use three of the original laboratories as regional quality control centers to address operational concerns and to accommodate the growth of the laboratory network to more than 20 countries including the Caribbean region. The overall EPT serotyping accuracies for phase I (1993 to 1998) and phase II (1999 to 2005) were 88.0 and 93.8%, respectively; the MIC correlations within 1 log2 dilution of the expected result were 83.0 and 91.0% and the interpretive category agreements were 89.1 and 95.3%. Overall, the validation process serotyping accuracies for phases I and II were 81.9 and 88.1%, respectively, 80.4 and 90.5% for MIC agreement, and 85.8 and 94.3% for category agreement. These results indicate a high level of testing accuracy in participating National Laboratories and a sustained increase in EQA participation in Latin America and the Caribbean.
Fil: Lovgren, Marguerite. National Centre for Streptococcus; Canadá.
Fil: Talbot, James A. National Centre for Streptococcus; Canadá.
Fil: Brandileone, Maria Cristina. Instituto Adolfo Lutz; Brazil.
Fil: Casagrande, Silvana T. Instituto Adolfo Lutz; Brazil.
Fil: Agudelo, Clara Inés. Instituto Nacional de Salud; Colombia.
Fil: Castañeda, Elizabeth. Instituto Nacional de Salud; Colombia.
Fil: Regueira, Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Heitmann, Ingrid. Instituto de Salud Pública; Chile.
Fil: Maldonado, Aurora. Instituto de Salud Pública; Chile.
Fil: Echániz-Avilés, Gabriela. Instituto Nacional de Salud Pública; Mexico.
Fil: Soto-Noguerón, Araceli. Instituto Nacional de Salud Pública; Mexico.
Fil: Hortal, María. Departamento de Laboratorios de Salud Pública; Uruguay.
Fil: Camou, Teresa. Departamento de Laboratorios de Salud Pública; Uruguay.
Fil: Gabastou, Jean-Marc. Pan American Health Organization/ World Health Organization. Area of Technology and Health Services Delivery; Estados Unidos.
Fil: Fabio, José Luis Di. Pan American Health Organization/ World Health Organization. Area of Technology and Health Services Delivery; Estados Unidos.
Fil: Grupo SIREVA; Estados Unidos.
URI: http://jcm.asm.org/content/45/10/3184.full.pdf+html
http://sgc.anlis.gob.ar/handle/123456789/279
ISSN: 1098-660X
Rights: info:eu-repo/semantics/openAccess
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