Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/262
Title: Prevalence of infection with hantavirus in rodent populations of central Argentina
Authors: Suárez, Olga V. 
Cueto, Gerardo 
Cavia, Regino 
Gómez Villafañe, Isabel E. 
Bilenca, David N. 
Edelstein, Alexis 
Martínez, Valeria Paula 
Miguel, Sergio 
Bellomo, Carla 
Hodara, Karina 
Padula, Paula 
Busch, María 
Keywords: Infecciones por Hantavirus;Enfermedades de los Roedores;Hantavirus;Síndrome Pulmonar por Hantavirus;Ensayo de Inmunoadsorción Enzimática;Argentina
Issue Date: 2003
Description: We studied hantavirus seroprevalence and virus variability in rodent populations in Diego Gaynor, northwest of Buenos Aires province, Argentina. Rodent samplings were conducted in railroads and cropfield borders in March and July 1999, September and December 2000, and March 2001. Antibody detection was performed by an enzyme link immunosorbent assay (ELISA), using the recombinant nucleoprotein of Andes (AND) virus as antigen. Tissue samples were taken from positive antibody individuals in order to confirm the presence of hantavirus genomic material and to identify virus genotypes. Akodon azaraewas the most abundant species, followed by Oligoryzomys flavescens, while Calomys laucha and C. musculinus were rarely caught. We found a rate of seroprevalence of 9.3% for a total sample of 291 A. azaraeand 13.5% for 37 O. flavescens. After molecular analyses of hantavirus, we confirmed the presence of hantavirus genomic material in 16 individuals with ELISA (+) results and two individuals with ELISA (-). Four amplimers for each species were sequenced and compared to the corresponding sequences of representative hantaviruses. We identified the AND Cent Lec from three O. flavescens, and the Pergamino virus from four A. azaraeand from one O. flavescens. A. azaraemales had higher seroprevalence than females, and heavier individuals showed higher seroprevalence than lighter ones. We did not find seroprevalence differences according to sex in O. flavescens,although this result may have been produced by the low sample size. The lowest seroprevalence was found in a period of high rodent density, when juveniles prevailed in the population. We found higher seroprevalences than those detected in previous studies for other localities of central Argentina where cases of hantavirus pulmonary syndrome (HPS) have been reported. The presence of AND Cent Lec virus in rodent populations of the study area, which is responsible of HPS cases in central Argentina, suggests that human populations are at risk of HPS disease, although there were not reported cases of this disease until today.
Fil: Suárez, Olga V. Facultad de Ciencias Exactas y Naturales. Laboratorio de Ecología de Poblaciones; Argentina.
Fil: Cueto, Gerardo. Facultad de Ciencias Exactas y Naturales. Laboratorio de Ecología de Poblaciones; Argentina.
Fil: Cavia, Regino. Facultad de Ciencias Exactas y Naturales. Laboratorio de Ecología de Poblaciones; Argentina.
Fil: Gómez Villafañe, Isabel E. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina.
Fil: Bilenca, David N. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina.
Fil: Edelstein, Alexis. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Martínez, Valeria Paula. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Miguel, Sergio. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Bellomo, Carla. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Hodara, Karina. Facultad de Ciencias Exactas y Naturales. Laboratorio de Ecología de Poblaciones; Argentina.
Fil: Padula, Paula. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
Fil: Busch, María. Consejo Nacional de Investigaciones Científicas y Tecnológicas; Argentina.
URI: http://www.scielo.br/pdf/mioc/v98n6/v98n6a03.pdf
http://sgc.anlis.gob.ar/handle/123456789/262
ISSN: 0074-0276
Rights: info:eu-repo/semantics/openAccess
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