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http://sgc.anlis.gob.ar/handle/123456789/2533
DC Field | Value | Language |
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dc.contributor.author | Caputo, María Belén | es |
dc.contributor.author | Elias, Josefina | es |
dc.contributor.author | Cesar, Gonzalo | es |
dc.contributor.author | Alvarez, María Gabriela | es |
dc.contributor.author | Laucella, Susana Adriana | es |
dc.contributor.author | Albareda, María Cecilia | es |
dc.date.accessioned | 2023-03-08T17:08:27Z | - |
dc.date.available | 2023-03-08T17:08:27Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/2533 | - |
dc.description | Fil: Caputo, María Belén. Investigation Department, Instituto Nacional de Parasitología Dr. Fatala Chaben; Buenos Aires, Argentina | es |
dc.description | Fil: Elias, Josefina. Investigation Department, Instituto Nacional de Parasitología Dr. Fatala Chaben; Buenos Aires, Argentina | es |
dc.description | Fil: Cesar, Gonzalo. Investigation Department, Instituto Nacional de Parasitología Dr. Fatala Chaben; Buenos Aires, Argentina | es |
dc.description | Fil: Alvarez, María Gabriela. Chagas Section, Hospital Interzonal General de Agudos Eva Perón; Buenos Aires, Argentina | es |
dc.description | Fil: Laucella, Susana Adriana. Chagas Section, Hospital Interzonal General de Agudos Eva Perón; Buenos Aires, Argentina | es |
dc.description | Fil: Albareda, María Cecilia. Investigation Department, Instituto Nacional de Parasitología Dr. Fatala Chaben; Buenos Aires, Argentina | es |
dc.description.abstract | Chagas disease, caused by the intracellular pathogen Trypanosoma cruzi, is the parasitic disease with the greatest impact in Latin America and the most common cause of infectious myocarditis in the world. The immune system plays a central role in the control of T. cruzi infection but at the same time needs to be controlled to prevent the development of pathology in the host. It has been shown that persistent infection with T. cruzi induces exhaustion of parasite-specific T cell responses in subjects with chronic Chagas disease. The continuous inflammatory reaction due to parasite persistence in the heart also leads to necrosis and fibrosis. The complement system is a key element of the innate immune system, but recent findings have also shown that the interaction between its components and immune cell receptors might modulate several functions of the adaptive immune system. Moreover, the findings that most of immune cells can produce complement proteins and express their receptors have led to the notion that the complement system also has non canonical functions in the T cell. During human infection by T. cruzi, complement activation might play a dual role in the acute and chronic phases of Chagas disease; it is initially crucial in controlling parasitemia and might later contributes to the development of symptomatic forms of Chagas disease due to its role in T-cell regulation. Herein, we will discuss the putative role of effector complement molecules on T-cell immune exhaustion during chronic human T. cruzi infection. | es |
dc.language.iso | en | es |
dc.relation.ispartof | Frontiers in cellular and infection microbiology | es |
dc.relation.ispartofseries | Front Cell Infect Microbiol;2022(12):1-6 | - |
dc.subject | Linfocitos T | es |
dc.subject | Trypanosoma Cruzi | es |
dc.subject | Anafilatoxinas | es |
dc.subject | Enfermedad de Chagas | es |
dc.title | Role of the Complement System in the Modulation of T-Cell Responses in Chronic Chagas Disease | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.3389/fcimb.2022.910854 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | Artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Instituto Nacional de Parasitología (INP) | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
Appears in Collections: | Artículos |
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File | Description | Size | Format | |
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10.3389fcimb.2022.910854.pdf | 877.06 kB | Adobe PDF | View/Open |
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