Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/2526
DC Field | Value | Language |
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dc.contributor.author | Caraballo, Diego A | es |
dc.contributor.author | Lema, Cristina L. | es |
dc.contributor.author | Novaro, Laura | es |
dc.contributor.author | Gury Dohmen, Federico | es |
dc.contributor.author | Russo, Susana | es |
dc.contributor.author | Beltrán, Fernando J | es |
dc.contributor.author | Palacios, Gustavo | es |
dc.contributor.author | Cisterna, Daniel | es |
dc.date.accessioned | 2023-03-08T16:51:04Z | - |
dc.date.available | 2023-03-08T16:51:04Z | - |
dc.date.issued | 2021-12-11 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/2526 | - |
dc.description | Fil: Caraballo, Diego A. Instituto de Ecología, Genética y Evolución de Buenos Aires (IEGEBA), CONICET-Universidad de Buenos Aires; Buenos Aires | es |
dc.description | Fil: Lema, Cristina. Servicio de Neurovirosis, Administración Nacional de Laboratorios e Institutos de Salud (ANLIS), Instituto Nacional de Enfermedades Infecciosas, "Dr. Carlos G. Malbrán"; Buenos Aires | es |
dc.description | Fil: Novaro, Laura. DILAB, SENASA; Buenos Aires | es |
dc.description | Fil: Gury-Dohmen, Federico. Instituto de Zoonosis "Dr. Luis Pasteur"; Buenos Aires | es |
dc.description | Fil: Russo, Susana. DILAB, SENASA; Buenos Aires | es |
dc.description | Fil: Beltrán, Fernando J. Instituto de Zoonosis "Dr. Luis Pasteur"; Buenos Aires | es |
dc.description | Fil: Palacios, Gustavo. Department of Microbiology, Icahn School of Medicine at Mount Sinai; United States | es |
dc.description | Fil: Cisterna, Daniel M. Servicio de Neurovirosis, Administración Nacional de Laboratorios e Institutos de Salud (ANLIS), Instituto Nacional de Enfermedades Infecciosas, "Dr. Carlos G. Malbrán"; Buenos Aires | es |
dc.description.abstract | The rabies virus (RABV) is characterized by a history dominated by host shifts within and among bats and carnivores. One of the main outcomes of long-term RABV maintenance in dogs was the establishment of variants in a wide variety of mesocarnivores. In this study, we present the most comprehensive phylogenetic and phylogeographic analysis, contributing to a better understanding of the origins, diversification, and the role of different host species in the evolution and diffusion of a dog-related variant endemic of South America. A total of 237 complete Nucleoprotein gene sequences were studied, corresponding to wild and domestic species, performing selection analyses, ancestral states reconstructions, and recombination analyses. This variant originated in Brazil and disseminated through Argentina and Paraguay, where a previously unknown lineage was found. A single host shift was identified in the phylogeny, from dog to the crab-eating fox (Cerdocyon thous) in the Northeast of Brazil. Although this process occurred in a background of purifying selection, there is evidence of adaptive evolution -or selection of sub-consensus sequences- in internal branches after the host shift. The interaction of domestic and wild cycles persisted after host switching, as revealed by spillover and putative recombination events. | es |
dc.language.iso | en | es |
dc.relation.ispartof | Viruses | es |
dc.subject | Perros | es |
dc.subject | turno de acogida | es |
dc.subject | Nucleoproteínas | es |
dc.subject | Filogenia | es |
dc.subject | Rabia | es |
dc.subject | Recombinación | es |
dc.subject | selección | es |
dc.title | A Novel Terrestrial Rabies Virus Lineage Occurring in South America: Origin, Diversification, and Evidence of Contact between Wild and Domestic Cycles | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.3390/v13122484 | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | Artículo | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Maestría en Microbiología Molecular UNSM-ANLIS | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.dept | Departamento de Virología | - |
crisitem.author.parentorg | Centro Nacional Red de Laboratorios (CNRL) | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.parentorg | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
Appears in Collections: | Artículos |
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File | Description | Size | Format | |
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viruses-13-02484.pdf | 3.34 MB | Adobe PDF | View/Open |
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