Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/2511
DC Field | Value | Language |
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dc.contributor.author | Le, Casin | es |
dc.contributor.author | Pimentel, Camila | es |
dc.contributor.author | Pasteran, Fernando | es |
dc.contributor.author | Tuttobene, Marisel R | es |
dc.contributor.author | Subils, Tomás | es |
dc.contributor.author | Escalante, Jenny | es |
dc.contributor.author | Nishimura, Brent | es |
dc.contributor.author | Arriaga, Susana | es |
dc.contributor.author | Carranza, Aimee | es |
dc.contributor.author | Mezcord, Vyanka | es |
dc.contributor.author | Vila, Alejandro J. | es |
dc.contributor.author | Corso, Alejandra | es |
dc.contributor.author | Actis, Luis A | es |
dc.contributor.author | Tolmasky, Marcelo E. | es |
dc.contributor.author | Bonomo, Robert A | es |
dc.contributor.author | Ramirez, Maria Soledad | es |
dc.date.accessioned | 2023-02-07T18:04:53Z | - |
dc.date.available | 2023-02-07T18:04:53Z | - |
dc.date.issued | 2022-03-03 | - |
dc.identifier.issn | 2227-9059 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/2511 | - |
dc.description | Fil: Le, Casin. Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton; United States | es |
dc.description | Fil: Pimentel, Camila. Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton; United States | es |
dc.description | Fil: Pasteran, Fernando. National/Regional Reference Laboratory for Antimicrobial Resistance (NRL), Servicio Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas, ANLIS Dr. Carlos G. Malbrán; Buenos Aires, Argentina | es |
dc.description | Fil: Tuttobene, Marisel R. Área Biología Molecular, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario; Rosario, Argentina | es |
dc.description | Fil: Subils, Tomás. Instituto de Procesos Biotecnológicos y Químicos de Rosario (IPROBYQ, CONICET-UNR); Rosario, Argentina | es |
dc.description | Fil: Escalante, Jenny. Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton; United States | es |
dc.description | Fil: Nishimura, Brent. Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton; United States | es |
dc.description | Fil: Arriaga, Susana. Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton; United States | es |
dc.description | Fil: Carranza, Aimee. Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton; United States | es |
dc.description | Fil: Mezcord, Vyanka. Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton; United States | es |
dc.description | Fil: Vila, Alejandro J. Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR); Rosario, Argentina | es |
dc.description | Fil: Corso, Alejandra. National/Regional Reference Laboratory for Antimicrobial Resistance (NRL), Servicio Antimicrobianos, Instituto Nacional de Enfermedades Infecciosas, ANLIS Dr. Carlos G. Malbrán; Buenos Aires, Argentina | es |
dc.description | Fil: Actis, Luis A. Department of Microbiology, Miami University; United States | es |
dc.description | Fil: Tolmasky, Marcelo E. Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton; United States | es |
dc.description | Fil: Bonomo, Robert A. Departments of Medicine, Pharmacology, Molecular Biology and Microbiology, Biochemistry, Proteomics and Bioinformatics, School of Medicine, Case Western Reserve University; United States | es |
dc.description | Fil: Ramírez, Maria Soledad. Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton; United States | es |
dc.description.abstract | Cefiderocol, a recently introduced antibiotic, has a chemical structure that includes a cephalosporin that targets cell wall synthesis and a chlorocatechol siderophore moiety that facilitates cell penetration by active iron transporters. Analysis of the effect that human serum, human serum albumin, and human pleural fluid had on growing Acinetobacter baumannii showed that genes related to iron uptake were down-regulated. At the same time, β-lactamase genes were expressed at higher levels. The minimum inhibitory concentrations of this antimicrobial in A. baumannii cells growing in the presence of human serum, human serum albumin, or human pleural fluid were higher than those measured when these fluids were absent from the culture medium. These results correlate with increased expression levels of β-lactamase genes and the down-regulation of iron uptake-related genes in cultures containing human serum, human serum albumin, or human pleural fluid. These modifications in gene expression could explain the less-than-ideal clinical response observed in patients with pulmonary or bloodstream A. baumannii infections. The exposure of the infecting cells to the host's fluids could cause reduced cefiderocol transport capabilities and increased resistance to β-lactams. The regulation of genes that could impact the A. baumannii susceptibility to cefiderocol, or other antibacterials, is an understudied phenomenon that merits further investigation. | es |
dc.language.iso | en | es |
dc.relation.ispartof | Biomedicines | es |
dc.subject | Acinetobacter baumannii | es |
dc.subject | cefiderocol | es |
dc.subject | human fluids | es |
dc.subject | human serum albumin | es |
dc.subject | iron | es |
dc.title | Human Serum Proteins and Susceptibility of Acinetobacter baumannii to Cefiderocol: Role of Iron Transport | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.3390/biomedicines10030600 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | Artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Servicio Antimicrobianos | - |
crisitem.author.dept | Departamento de Bacteriología | - |
crisitem.author.dept | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.dept | Departamento de Bacteriología | - |
crisitem.author.dept | Servicio Antimicrobianos | - |
crisitem.author.parentorg | Departamento de Bacteriología | - |
crisitem.author.parentorg | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.parentorg | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.parentorg | Departamento de Bacteriología | - |
Appears in Collections: | Artículos |
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biomedicines-10-00600.pdf | 3.4 MB | Adobe PDF | View/Open |
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