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Title: | Exploring the value of MALDI-TOF MS for the detection of clonal outbreaks of Burkholderia contaminans | Authors: | Fiamanya, Selali Cipolla, Lucía Prieto, Mónica A. Stelling, John |
Keywords: | Brotes de Enfermedades;Burkholderia;Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción | Issue Date: | 2021 | Journal: | Journal of microbiological methods | Abstract: | Molecular genetics has risen in both output and affordability to become the gold standard in diagnosis, however it is not yet available for most routine clinical microbiology due to cost and the level of skill it requires. Matrix assisted laser desorption/ionisation - time of flight mass spectrometry (MALDI-TOF MS) approaches may be useful in bridging the gap between low-resolution phenotypic methods and bulky genotypic methods in the goal of epidemiological source-typing of microbes. Burkholderia has been shown to be identifiable at the subspecies level using MALDI-TOF MS. There have not yet been studies assessing the ability of MALDI-TOF MS to source-type Burkholderia contaminans isolates into epidemiologically relevant outbreak clusters. |
Description: | Fil. Fiamanya, Selali. Escuela de Graduados Académicos Clínicos de la Universidad de Oxford, Hospital John Radcliffe, Oxford OX3 9DU, Reino Unido. Fil. Cipolla, Lucía. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Bacteriología Especial; Argentina. Fil. Prieto, Mónica. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Bacteriología Especial; Argentina. Fil. Stelling, John. Departamento de Medicina, División de Enfermedades Infecciosas, Hospital Brigham and Women's, 75 Francis Street, Boston, MA 02115, EE. UU. Departamento de Medicina, Facultad de Medicina de Harvard 25 Shattuck Street, Boston, MA 02115, EE. UU. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/2407 | DOI: | 10.1016/j.mimet.2020.106130 |
Appears in Collections: | Publicaciones INEI |
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1-s2.0-S0167701220308460-main inei 3 8-11.pdf | Artículo en inglés | 4.39 MB | Adobe PDF | View/Open |
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