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Título: | Clinical isolates of Mycobacterium tuberculosis differ in their ability to induce respiratory burst and apoptosis in neutrophils as a possible mechanism of immune escape | Autor(es): | Romero, María Mercedes Balboa, Luciana Basile, Juan Ignacio López, Beatriz Ritacco, Viviana de la Barrera, Silvia Sasiain, María C. Barrera, Lucía Alemán, Mercedes |
Palavras-chave: | Mycobacterium tuberculosis;Neutrófilos;Estallido Respiratorio;Apoptosis | Data do documento: | 2012 | Jornal: | Clinical & developmental immunology | Resumo: | Tuberculosis pathogenesis was earlier thought to be mainly related to the host but now it appears to be clear that bacterial factors are also involved. Genetic variability of Mycobacterium tuberculosis (Mtb) could be slight but it may lead to sharp phenotypic differences. We have previously reported that nonopsonized Mtb H37Rv induce apoptosis of polymorphonuclear neutrophils (PMNs) by a mechanism that involves the p38 pathway. Here we evaluated the capability to induce PMN apoptosis of two prevalent Mtb lineages in Argentina, the Latin America and Mediterranean (LAM), and Haarlem, using the H37Rv as a reference strain. Results showed that LAM strains strongly induced apoptosis of PMN which correlated with the induction of reactive oxygen species (ROS) production and p38 activation. Interestingly, the highly prosperous multidrug-resistant M strain, belonging to the Haarlem lineage, lacked the ability to activate and to induce PMN apoptosis as a consequence of (1) a weak ROS production and (2) the contribution of antiapoptotic mechanisms mediated at least by ERK. Although with less skill, M is able to enter the PMN so that phenotypic differences could lead PMN to be a reservoir allowing some pathogens to prevail and persist over other strains in the community. |
Descrição: | Fil: Romero, María Mercedes. Academia Nacional de Medicina. Instituto de Medicina Experimental; Argentina. Fil: Balboa, Luciana. Academia Nacional de Medicina. Instituto de Medicina Experimental; Argentina. Fil: Basile, Juan Ignacio. Academia Nacional de Medicina. Instituto de Medicina Experimental; Argentina. Fil: López, Beatriz. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Microbacterias; Argentina. Fil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Microbacterias; Argentina. Fil: de la Barrera, Silvia. Academia Nacional de Medicina. Instituto de Medicina Experimental; Argentina. Fil: Sasiain, María C. Academia Nacional de Medicina. Instituto de Medicina Experimental; Argentina. Fil: Barrera, Lucía. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio de Microbacterias; Argentina. Fil: Alemán, Mercedes. Academia Nacional de Medicina. Instituto de Medicina Experimental; Argentina. |
URI: | https://downloads.hindawi.com/journals/jir/2012/152546 http://sgc.anlis.gob.ar/handle/123456789/2288 |
DOI: | 10.1155/2012/152546 | Direitos: | Creative Commons Attribution 4.0 International License |
Aparece nas Coleções: | Publicaciones INEI |
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Arquivo | Descrição | Tamanho | Formato | |
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CDI_2012_152546.pdf | Artículo en inglés | 5.4 MB | Adobe PDF | Ver/Aberto |
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Este item está licenciada sob uma Licença Creative Commons