Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/2253
DC Field | Value | Language |
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dc.contributor.author | Cuppari, Anahi Fernandez | es |
dc.contributor.author | Sanchez, Vanesa | es |
dc.contributor.author | Ledesma, Bibiana A | es |
dc.contributor.author | Frank, Fernanda M. | es |
dc.contributor.author | Goldman, Alejandra | es |
dc.contributor.author | Angel, Sergio O. | es |
dc.contributor.author | Martín, Valentina | es |
dc.date.accessioned | 2021-01-26T15:42:24Z | - |
dc.date.available | 2021-01-26T15:42:24Z | - |
dc.date.issued | 2008-09-15 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/2253 | - |
dc.description | Fil: Cuppari, Anahi Fernandez. Laboratorio de Inmunología, Centro de Salud y Medio Ambiente, E.C.y T., Universidad de Gral. San Martín, Provincia de Buenos Aires; Argentina. | es |
dc.description | Fil: Sanchez, Vanesa. Laboratorio de Inmunología, Centro de Salud y Medio Ambiente, E.C.y T., Universidad de Gral. San Martín, Provincia de Buenos Aires; Argentina. | es |
dc.description | Fil: Ledesma, Bibiana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Parasitología; Argentina. | es |
dc.description | Fil: Frank, Fernanda M. Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, and Facultad de Farmacia y Bioquímica, IDEHU, CONICET Universidad de Buenos Aires, Buenos Aires; Argentina | es |
dc.description | Fil: Goldman, Alejandra. Laboratorio de Inmunología, Centro de Salud y Medio Ambiente, E.C.y T., Universidad de Gral. San Martín, Provincia de Buenos Aires, Argentina. | es |
dc.description | Fil: Angel, Sergio O. Laboratorio de Parasitología Molecular, IIB-INTECH, CONICET-UNSAM, Chascomús, Provincia de Buenos Aires, Argentina. | es |
dc.description | Fil: Martin, Valentina. Laboratorio de Inmunología, Centro de Salud y Medio Ambiente, E.C.y T., Universidad de Gral. San Martín, Provincia de Buenos Aires; Argentina. | es |
dc.description.abstract | The Toxoplasma gondii serin protease inhibitor-1 (TgPI-1) is a dense granule antigen that showed to specifically inhibit trypsin, chymotrypsin and neutrophil elastase, suggesting a possible modulatory role during the parasite invasion process and on the development of the innate immune response. To study the immune-protective value of TgPI-1, C3H/HeN mice were immunized with a recombinant form of the antigen rTgPI-1 combined with alum. All immunized mice produced specific anti-rTgPI-1 immunoglobulins, with high IgG antibody titers and a mixed IgG(1)/IgG(2a) response, with predominance of IgG(1) production. The cellular immune response was associated with the production of IFN-gamma and IL-10 cytokines. Vaccinated mice displayed significant protection against an oral challenge either after a lethal infection with Me49 cysts (90% survival vs. 50%) and also after a non-lethal infection (58% reduction in brain parasite load) compared to the non-vaccinated control group. In conclusion, rTgPI-1 elicits a strong specific immune response providing partial protection against both T. gondii acute and chronic infection, so it would be a good candidate in a vaccine against toxoplasmosis, which could be combined with other relevant parasite antigens. | es |
dc.language.iso | en | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Vaccine | es |
dc.rights | Closed Access | - |
dc.source | Vaccine 2008; 26(39):5040-5. | - |
dc.subject | Toxoplasma | es |
dc.subject | Toxoplasmosis | es |
dc.title | Toxoplasma gondii protease inhibitor-1 (TgPI-1) is a novel vaccine candidate against toxoplasmosis | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1016/j.vaccine.2008.07.031 | - |
anlis.essnrd | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | Artículo | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
Appears in Collections: | Publicaciones INEI |
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