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Título : Pandemic influenza A/H1N1 2009 antibodies in the metropolitan area of Buenos Aires in Argentina
Autor : Labato, Mariana I 
Contrini, María M 
Lazzarini, Daniela 
Campos, Ana 
Gauna, María L 
Claros, Ronald 
Lopez, Eduardo L. 
Savy, Vilma L. 
Luna, Carlos M 
Palabras clave : Virus de la Influenza A;Prevalencia;Estudios Seroepidemiológicos
Fecha de publicación : feb-2014
Journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 
Resumen : 
Objective
To estimate the infection prevalence in Buenos Aires during the outbreak of pandemic influenza A/H1N1 2009 virus (A(H1N1)pdm09).
Methods
A(H1N1)pdm09-specific antibodies were measured by hemagglutination inhibition assay in human serum samples collected 6 months after the outbreak and before the introduction of the A(H1N1)pdm09 vaccine in Argentina. Baseline levels of cross-reactive antibodies to A(H1N1)pdm09 were determined by testing 162 serum samples collected before 2009.
Results
The overall seroprevalence of A(H1N1)pdm09 in 150 children and 427 adults was 28.9% (95% confidence interval (CI) 25–33%), with a 58.0% prevalence in children <19 years of age and an 18.7% prevalence in adults ≥19 years of age (p < 0.001). The prevalence was 43.5% in children <5 years old and 60.6% among children aged 5–18 years. The prevalence in adults declined with increasing age: 24.9% in 19–39-year-olds, 9.7% in 40–59-year-olds, and 8.1% in those ≥60 years old. The prevalence of specific A(H1N1)pdm09 antibodies was higher compared with the baseline in children (p = 0.014), adolescents (p < 0.001), and adults <40 years old (p = 0.017). Seroprevalence in health care workers was not different from the rest of the population (13.6% vs. 19.3%, respectively; p = 0.421).
Conclusions
The prevalence of specific A(H1N1)pdm09 antibodies was high at 28.9%. The highest prevalence was observed in children, adolescents, and young adults.
Descripción : 
Fil: Labato, Mariana I. Universidad de Buenos Aires. Hospital de Clínicas "José de San Martín", Buenos Aires; Argentina.

Fil: Contrini, María M. Hospital de Niños "Ricardo Gutiérrez", Buenos Aires; Argentina.

Fil: Lazzarini, Daniela. Hospital de Niños "Ricardo Gutiérrez", Buenos Aires; Argentina.

Fil: Campos, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.

Fil: Gauna, María L. Universidad de Buenos Aires. Hospital de Clínicas "José de San Martín", Buenos Aires; Argentina.

Fil: Claros, Ronald. Universidad de Buenos Aires. Hospital de Clínicas "José de San Martín", Buenos Aires; Argentina.

Fil: López, Eduardo L. Hospital de Niños "Ricardo Gutiérrez", Buenos Aires; Argentina.

Fil: Savy, Vilma L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.

Fil: Luna, Carlos M. Universidad de Buenos Aires. Hospital de Clínicas "José de San Martín", Buenos Aires; Argentina.
URI : https://www.ijidonline.com/article/S1201-9712(13)00313-5/fulltext
http://sgc.anlis.gob.ar/handle/123456789/2230
DOI: 10.1016/j.ijid.2013.09.021
Derechos: Open Access
Creative Commons Attribution 4.0 International License
Aparece en las colecciones: Publicaciones INEI

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