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Title: | Seroincidence and phylogeny of human immunodeficiency virus infections in a cohort of commercial sex workers in Montevideo, Uruguay | Authors: | Viñoles, Jose Serra, Margarita Russi, J. Ruchansky, Dora Sosa-Estani, Sergio Montano, Silvia M Carrion, Gladys Eyzaguirre, Lindsay Carr, Jean K Olson, James G Bautista, Christian Sánchez, José L Weissenbacher, Mercedes C. |
Keywords: | VIH;Uruguay | Issue Date: | Apr-2005 | Publisher: | American Society of Tropical Medicine and Hygiene | Journal: | The American journal of tropical medicine and hygiene | Abstract: | A cohort study involving 60 human immunodeficiency virus (HIV)-negative male transvestite commercial sex workers (CSWs) was conducted in Montevideo, Uruguay in 1999-2001. Serum samples were tested for HIV by an enzyme-linked immunosorbent assay screening with immunoblot confirmation. Six participants seroconverted for an incidence-density rate of 6.03 (95% confidence interval = 2.21-13.12) per 100 person-years. Inconsistent condom use during client sex (adjusted hazard ratio [AHR] = 6.7), during oral sex (AHR = 5.6), and at the last sexual encounter (AHR = 7.8), and use of marihuana (AHR = 5.4) were marginally associated with HIV seroconversion. Five samples were genotyped in the protease and reverse transcriptase regions; three were subtypes B and two were BF recombinants. Full genome analysis of four samples confirmed all three subtype B samples and one of the two BF recombinants. Male transvestite CSWs sustained a high rate of HIV infection. Larger prospective studies are required to better define subtypes and associated sexual and drug-related risk factors. |
Description: | Fil: Viñoles, Jose. HIV/AIDS National Control Program, and Department of Laboratories of Public Health, Ministry of Health, Montevideo; Uruguay. Fil: Serra, Margarita. HIV/AIDS National Control Program, and Department of Laboratories of Public Health, Ministry of Health, Montevideo; Uruguay. Fil: Russi, J. Ministerio de Salud Pública. Departamento de Laboratorios; Uruguay. Fil: Ruchansky, Dora. Servicio de Virología Molecular, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain. Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación en Endemo-Epidemias; Argentina. Fil: Montano, Silvia M. US Naval Medical Research Center Detachment-Lima; Peru. Fil: Carrion, Gladys. US Naval Medical Research Center Detachment (NMRCD). Unit 3800, APO-AA 34031-3800, Lima; Peru. Fil: Eyzaguirre, Lindsay. Department of Epidemiology, Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, Baltimore; Estados Unidos. Fil: Carr, Jean K. US Military HIV Research Program and Henry M. Jackson Foundation, Rockville, MD; Estados Unidos. Fil: Olson, James G. US Naval Medical Research Center Detachment-Lima; Peru. Fil: Bautista, Christian T. US Military HIV Research Program at the Walter Reed Army Institute of Research, Division of Retrovirology, the Henry M Jackson Foundation for the Advancement Military Medicine, Inc, Rockville, MD; Estados Unidos. Fil: Sanchez, Jose L. US Military HIV Research Program and Henry M. Jackson Foundation, Rockville, MD; Estados Unidos. Fil: Weissenbacher, Mercedes. Centro Nacional de Referencia de SIDA, Universidad de Buenos Aires; Argentina. |
URI: | https://www.ajtmh.org/docserver/fulltext/14761645/72/4/0720495.pdf?expires=1611229975&id=id&accname=guest&checksum=5AA86A3028655B88B85F9E115695341A http://sgc.anlis.gob.ar/handle/123456789/2219 |
ISSN: | 0002-9637 | Rights: | Open Access Creative Commons Attribution 4.0 International License |
Appears in Collections: | Publicaciones CeNDIE |
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Am. J. Trop. Med. Hyg_2005_72_4_2005_495–500.pdf | Artículo en inglés | 218.44 kB | Adobe PDF | View/Open |
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