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http://sgc.anlis.gob.ar/handle/123456789/2199| Title: | Phenotypic and Molecular Evaluation of Echinocandin Susceptibility of Candida glabrata, Candida bracarensis, and Candida nivariensis Strains Isolated during 30 Years in Argentina | Authors: | Morales López, Soraya Eugenia Dudiuk, Catiana Vivot, Walter Szusz, Wanda Córdoba, Susana Garcia-Effron, Guillermo |
Keywords: | Candida;Anidulafungina;Argentina | Issue Date: | 27-Jun-2017 | Journal: | Antimicrobial agents and chemotherapy | Abstract: | The echinocandin susceptibilities of 122 Candida glabrata complex strains (including 5 Candida nivariensis and 3 Candida bracarensis strains) were evaluated by microdilution and compared with the results from a molecular tool able to detect FKS mutations. No echinocandin resistance was detected. The PCR results coincide with the MIC data in 99.25% of the cases (1 C. glabrata strain was misidentified as resistant) but were 20 h faster. C. nivariensis FKS genes were sequenced and showed differences with C. glabrataFKS genes. |
Description: | Fil: Morales López, Soraya Eugenia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina. Fil: Dudiuk, Catiana. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Parasitología y Micología. Laboratorio de Micología y Diagnóstico Molecular, Santa Fe; Argentina. Fil: Vivot, Walter. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina. Fil: Szusz, Wanda. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina. Fil: Córdoba, Susana B. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina. Fil: Garcia-Effron, Guillermo. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Parasitología y Micología. Laboratorio de Micología y Diagnóstico Molecular, Santa Fe; Argentina. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/2199 | ISSN: | 1098-6596 | DOI: | 10.1128/AAC.00170-17 | Rights: | Open Access Creative Commons Attribution 4.0 International License |
| Appears in Collections: | Publicaciones INEI |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| AntimicrobialAgentsandChemotherapy_2017_61_7_e00170-17.pdf | 227.34 kB | Adobe PDF | View/Open |
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