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Título : | Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses | Autor : | Clark, Lars E Mahmutovic, Selma Raymond, Donald D Dilanyan, Taleen Koma, Takaaki Manning, John T Shankar, Sundaresh Levis, Silvana Briggiler, Ana M. Enria, Delia Wucherpfennig, Kai W Paessler, Slobodan Abraham, Jonathan |
Palabras clave : | Arenavirus;Fiebre Hemorrágica Americana | Fecha de publicación : | may-2018 | Editorial : | Yes | Journal: | Nature communications | Resumen : | While five arenaviruses cause human hemorrhagic fevers in the Western Hemisphere, only Junin virus (JUNV) has a vaccine. The GP1 subunit of their envelope glycoprotein binds transferrin receptor 1 (TfR1) using a surface that substantially varies in sequence among the viruses. As such, receptor-mimicking antibodies described to date are type-specific and lack the usual breadth associated with this mode of neutralization. Here we isolate, from the blood of a recipient of the live attenuated JUNV vaccine, two antibodies that cross-neutralize Machupo virus with varying efficiency. Structures of GP1-Fab complexes explain the basis for efficient cross-neutralization, which involves avoiding receptor mimicry and targeting a conserved epitope within the receptor-binding site (RBS). The viral RBS, despite its extensive sequence diversity, is therefore a target for cross-reactive antibodies with activity against New World arenaviruses of public health concern. |
Descripción : | Fil: Clark, Lars E. Department of Microbiology and Immunobiology, Harvard Medical School, Boston; Estados Unidos. Fil: Mahmutovic, Selma. Laboratory of Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston; Estados Unidos. Fil: Raymond, Donald D. Laboratory of Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston; Estados Unidos. Fil: Dilanyan, Taleen. Department of Microbiology and Immunobiology, Harvard Medical School, Boston; Estados Unidos. Fil: Koma, Takaaki. Department of Pathology, University of Texas Medical Branch at Galveston, Galveston; Estados Unidos. Fil: Manning, John T. Department of Pathology, University of Texas Medical Branch at Galveston, Galveston; Estados Unidos. Fil: Shankar, Sundaresh. Department of Microbiology and Immunobiology, Harvard Medical School, Boston; Estados Unidos. Fil: Levis, Silvana C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina. Fil: Briggiler, Ana M. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina. Fil: Enria, Delia A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina. Fil: Wucherpfennig, Kai W. Laboratory of Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston; Estados Unidos. Fil: Paessler, Slobodan. Department of Pathology, University of Texas Medical Branch at Galveston, Galveston; Estados Unidos. Fil: Abraham, Jonathan. Department of Microbiology and Immunobiology, Harvard Medical School, Boston; Estados Unidos. |
URI : | http://sgc.anlis.gob.ar/handle/123456789/2131 | ISSN : | 2041-1723 | DOI: | 10.1038/s41467-018-04271-z | Derechos: | Open Access Creative Commons Attribution 4.0 International License |
Aparece en las colecciones: | Publicaciones INEVH |
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10.1038_s41467-018-04271-z..pdf | Artículo en inglés | 4.3 MB | Adobe PDF | Visualizar/Abrir |
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