Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/2040
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dokmetjian, Christian | es |
dc.contributor.author | Del Canto, Sergio | es |
dc.contributor.author | Vinzón, Sabrina | es |
dc.contributor.author | Biscoglio de Jiménez Bonino, Mirtha | es |
dc.date.accessioned | 2021-01-05T21:20:43Z | - |
dc.date.available | 2021-01-05T21:20:43Z | - |
dc.date.issued | 2009-03-01 | - |
dc.identifier.issn | 0041-0101 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/2040 | - |
dc.description | Fil: Dokmetjian, Christian. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina. | es |
dc.description | Fil: Del Canto, Sergio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica. Instituto de Química y Fisicoquímica Biológicas; Argentina. | es |
dc.description | Fil: Vinzón, Sabrina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica. Instituto de Química y Fisicoquímica Biológicas; Argentina. | es |
dc.description | Fil: Biscoglio de Jiménez Bonino, Mirtha. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica. Instituto de Química y Fisicoquímica Biológicas; Argentina. | es |
dc.description.abstract | Snake venom toxicity is the consequence of a combination of peptides and proteins whose identification and characterization are of great importance to understand envenomation and develop new clinical treatments. The Elapinae subfamily includes coral snakes whose bite causes mainly neurotoxic effects which disable muscle contraction and paralyse the heart as well as inhibit respiration. However, the structure-function relationship of venom toxins has been investigated only for a few species. We herein study biological aspects of the Micrurus pyrrhocryptus venom such as LD(50), hemorrhagic, necrotic, coagulant, myotoxic and hemolytic activity as well as the ability of venom components to compete with alpha-Bungarotoxin for the ligand-binding site of the nicotinic acetylcholine receptor. Besides, we report the determination of the molecular mass and N-terminal sequence of toxins including PLA2s, short, long and weak neurotoxins. The complete sequence of one of the short neurotoxins has also been obtained, this being the first sequence of an alpha-neurotoxin determined in the M. pyrrhocryptus venom and one of the few fully determined in members of the Micrurus genus. | es |
dc.language.iso | en | es |
dc.relation.ispartof | Toxicon : official journal of the International Society on Toxinology | es |
dc.rights | Closed Access | - |
dc.subject | Neurotoxinas | es |
dc.subject | Hemorragia | es |
dc.subject | Venenos Elapídicos | es |
dc.subject | Receptores Nicotínicos | es |
dc.subject | Venenos de Serpiente | es |
dc.title | Biochemical characterization of the Micrurus pyrrhocryptus venom | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1016/j.toxicon.2008.12.015 | - |
anlis.essnrd | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | Artículo | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Instituto Nacional de Producción de Biológicos (INPB) | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
Appears in Collections: | Publicaciones INPB |
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