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http://sgc.anlis.gob.ar/handle/123456789/203| Title: | Identification of the Novel Narrow-Spectrum β-Lactamase SCO-1 in Acinetobacter spp. from Argentina | Authors: | Poirel, Laurent Corvec, Stéphane Rapoport, Melina J. Mugnier, Pauline D. Petroni, Alejandro Pasteran, Fernando Faccone, Diego Galas, Marcelo F. Drugeon, Henri Cattoir, Vincent Nordmann, Patrice |
Keywords: | Resistencia beta-Lactámica;Infecciones por Acinetobacter;Antibacterianos;Ácido Clavulánico;Datos de Secuencia Molecular;Pruebas de Sensibilidad Microbiana;Clonación Molecular | Issue Date: | 2007 | Description: | By studying the -lactamase content of several Acinetobacter spp. isolates from Argentina, producing the expanded-spectrum -lactamases (ESBL) VEB-1a or PER-2, a novel Ambler class A -lactamase gene was identified. It encoded the narrow-spectrum -lactamase SCO-1, whose activity was inhibited by clavulanic acid. SCO-1 hydrolyzes penicillins at a high level and cephalosporins and carbapenems at a very low level. -Lactamase SCO-1 was identified from unrelated VEB-1a-positive or PER-2-positive Acinetobacter spp. isolates recovered from three hospitals. The blaSCO-1 gene was apparently located on a plasmid of ca. 150 kb from all cases but was not associated with any ESBL-encoding gene. The G C content of the blaSCO gene was 52%, a value that does not correspond to that of the A. baumannii genome (39%). -Lactamase SCO-1 shares 47% amino acid identity with CARB-5 and ca. 40% with the enzymes TEM, SHV, and CTX-M. A gene encoding a putative resolvase was identified downstream of the blaSCO-1 gene, but its precise way of acquisition remains to be determined. Fil: Poirel, Laurent. Assistance Publique. Service de Bactériologie-Virologie; Francia. Fil: Corvec, Stéphane. Assistance Publique. Service de Bactériologie-Virologie; Francia. Fil: Rapoport, Melina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Depertamento Bacteriologia. Servicio de Antimicrobianos; Argentina. Fil: Mugnier, Pauline. Assistance Publique. Service de Bactériologie-Virologie; Francia. Fil: Petroni, Alejandro. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Depertamento Bacteriologia. Servicio de Antimicrobianos; Argentina. Fil: Pasteran, Fernando. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Depertamento Bacteriologia. Servicio de Antimicrobianos; Argentina. Fil: Faccone, Diego. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Depertamento Bacteriologia. Servicio de Antimicrobianos; Argentina. Fil: Galas, Marcelo F. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Depertamento Bacteriologia. Servicio de Antimicrobianos; Argentina. Fil: Drugeon, Henri. Centre Hospitalier Universitaire (CHU). Laboratoire de Bactériologie-Virologie; Francia. Fil: Nordmann, Patrice. Assistance Publique. Service de Bactériologie-Virologie; Francia. Fil: Cattoir, Vincent. Assistance Publique. Service de Bactériologie-Virologie; Francia. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/203 http://aac.asm.org/content/51/6/2179.full.pdf+html |
ISSN: | 1098-6596 | Rights: | info:eu-repo/semantics/openAccess |
| Appears in Collections: | snrd Publicaciones INEI |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| AntimicrobialAgentsandChemotherapy,2007,51(6),2179–2184..pdf | 349.92 kB | Adobe PDF |  View/Open |
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