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Título : Genomic resolution of an aggressive, widespread, diverse and expanding meningococcal serogroup B, C and W lineage
Autor : Lucidarme, Jay 
Hill, Dorothea M C 
Bratcher, Holly B 
Gray, Steve J 
du Plessis, Mignon 
Tsang, Raymond S W 
Vázquez, Julio A. 
Taha, Muhamed-Kheir 
Ceyhan, Mehmet 
Efron, Adriana M. 
Gorla, María Cecilia 
Findlow, Jamie 
Jolley, Keith A. 
Maiden, Martin C J 
Borrow, Ray 
Palabras clave : Genoma;Brotes de Enfermedades;Enfermedades Endémicas;Francia;Homosexualidad Masculina;Humanos;Masculino;Infecciones Meningocócicas;Neisseria meningitidis;Neisseria meningitidis Serogrupo B;Neisseria meningitidis Serogrupo C;América del Norte;Filogenia;Serogrupo;Serotipificación;Sudáfrica;América del Sur;Reino Unido;Tipificación de Secuencias Multilocus
Fecha de publicación : nov-2015
Editorial : British Infection Society
Elsevier
Proyecto: datasets
Journal: The Journal of infection 
Resumen : 
Objectives: Neisseria meningitidis is a leading cause of meningitis and septicaemia. The hyperinvasive ST-11 clonal complex (cc11) caused serogroup C (MenC) outbreaks in the US military in the 1960s and UK universities in the 1990s, a global Hajj-associated serogroup W (MenW) outbreak in 2000-2001, and subsequent MenW epidemics in sub-Saharan Africa. More recently, endemic MenW disease has expanded in South Africa, South America and the UK, and MenC cases have been reported among European and North American men who have sex with men (MSM). Routine typing schemes poorly resolve cc11 so we established the population structure at genomic resolution.

Methods: Representatives of these episodes and other geo-temporally diverse cc11 meningococci (n = 750) were compared across 1546 core genes and visualised on phylogenetic networks.

Results: MenW isolates were confined to a distal portion of one of two main lineages with MenB and MenC isolates interspersed elsewhere. An expanding South American/UK MenW strain was distinct from the 'Hajj outbreak' strain and a closely related endemic South African strain. Recent MenC isolates from MSM in France and the UK were closely related but distinct.

Conclusions: High resolution 'genomic' multilocus sequence typing is necessary to resolve and monitor the spread of diverse cc11 lineages globally.
Descripción : 
Fil: Lucidarme, Jay. Public Health England. Manchester Medical Microbiology Partnership. Manchester Royal Infirmary. Vaccine Evaluation Unit; Reino Unido.

Fil: Hill, Dorothea M C. University of Oxford. Department of Zoology; Reino Unido.

Fil: Bratcher, Holly B. University of Oxford. Department of Zoology; Reino Unido.

Fil: Gray, Steve J. Public Health England. Manchester Medical Microbiology Partnership. Manchester Royal Infirmary. Meningococcal Reference Unit; Reino Unido.

Fil: du Plessis, Mignon. Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases, National Health Laboratory Service, 1 Modderfontein Road, Sandringham, Johannesburg, 2131, South Africa.

Fil: Tsang, Raymond S W. Public Health Agency of Canada. National Microbiology Laboratory; Canadá.

Fil: Vázquez, Julio A. Institute of Health Carlos III. Reference Laboratory for Meningococci; España.

Fil: Taha, Muhamed-Kheir. Institut Pasteur. Département Infection et Epidémiologie. Unité des Infections Bactériennes invasives; Francia.

Fil: Ceyhan, Mehmet. Hacettepe University. Faculty of Medicine; Turquía.

Fil: Efron, Adriana M. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Bacteriología Clínica; Argentina.

Fil: Gorla, Maria C. Adolfo Lutz Institute. Bacteriology Department. Division of Medical Biology; Brasil.

Fil: Findlow, Jamie. Public Health England. Manchester Medical Microbiology Partnership. Manchester Royal Infirmary. Vaccine Evaluation Unit; Reino Unido.

Fil: Jolley, Keith A. University of Oxford. Department of Zoology; Reino Unido.

Fil: Maiden, Martin C J. University of Oxford. Department of Zoology; Reino Unido.

Fil: Borrow, Ray. Public Health England. Manchester Medical Microbiology Partnership. Manchester Royal Infirmary. Vaccine Evaluation Unit; Reino Unido.
URI : http://sgc.anlis.gob.ar/handle/123456789/2021
DOI: 10.1016/j.jinf.2015.07.007
Derechos: Open Access
Aparece en las colecciones: Publicaciones INEI

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