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Title: | Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations | Authors: | Chan, Paul K. S. Zhang, Chuqing Park, Jong-Sup Smith-McCune, Karen K. Palefsky, Joel M. Giovannelli, Lucia Coutlee, Francois Hibbitts, Samantha Konno, Ryo Settheetham-Ishida, Wannapa Chu, Tang-Yuan Ferrera, Annabelle Picconi, María Alejandra De Marco, Federico Woo, Yin-Ling Raiol, Taina Pina-Sanchez, Patricia Bae, Jeong-Hoon Wong, Martin C S Chirenje, Mike Z. Magure, Tsitsi Moscicki, Anna-Barbara Fiander, Alison N. Capra, Giuseppina Young Ki, Eun Tan, Yi Chen, Zigui Burk, Robert D Chan, Martin C W Cheung, Tak-Hong Pim, David Banks, Lawrence |
Keywords: | Biomarcadores de Tumor;Proteínas de la Cápside;Neoplasia Intraepitelial Cervical;Cuello del Útero;ADN de Neoplasias;Femenino;Estudios de Seguimiento;Variación Genética;Geografía;Humanos;Agencias Internacionales;Proteínas Oncogénicas Virales;Papillomaviridae;Proteínas E7 de Papillomavirus;Infecciones por Papillomavirus;Filogenia;Reacción en Cadena de la Polimerasa;Pronóstico;Medición de Riesgo;Neoplasias del Cuello Uterino | Issue Date: | 1-Jun-2013 | Publisher: | Wiley International Union against Cancer |
Project: | datasets | Journal: | International journal of cancer | Abstract: | Human papillomavirus (HPV) 58 accounts for a notable proportion of cervical cancers in East Asia and parts of Latin America, but it is uncommon elsewhere. The reason for such ethnogeographical predilection is unknown. In our study, nucleotide sequences of E6 and E7 genes of 401 HPV58 isolates collected from 15 countries/cities across four continents were examined. Phylogenetic relationship, geographical distribution and risk association of nucleotide sequence variations were analyzed. We found that the E6 genes of HPV58 variants were more conserved than E7. Thus, E6 is a more appropriate target for type-specific detection, whereas E7 is more appropriate for strain differentiation. The frequency of sequence variation varied geographically. Africa had significantly more isolates with E6-367A (D86E) but significantly less isolates with E6-203G, -245G, -367C (prototype-like) than other regions (p ≤ 0.003). E7-632T, -760A (T20I, G63S) was more frequently found in Asia, and E7-793G (T74A) was more frequent in Africa (p < 0.001). Variants with T20I and G63S substitutions at E7 conferred a significantly higher risk for cervical intraepithelial neoplasia grade III and invasive cervical cancer compared to other HPV58 variants (odds ratio = 4.44, p = 0.007). In conclusion, T20I and/or G63S substitution(s) at E7 of HPV58 is/are associated with a higher risk for cervical neoplasia. These substitutions are more commonly found in Asia and the Americas, which may account for the higher disease attribution of HPV58 in these areas. |
Description: | Fil: Chan, Paul K S. The Chinese University of Hong Kong. Faculty of Medicine. Department of Microbiology; China. Fil: Zhang, Chuqing. The Chinese University of Hong Kong. Faculty of Medicine. Department of Microbiology; China. Fil: Park, Jong-Sup. The Catholic University of Korea. Seoul St. Mary's Hospital. Department of Obstetrics and Gynecology; Corea del Sur. Fil: Smith-McCune, Karen K. University of California San Francisco. Department of Obstetrics, Gynecology and Reproductive Sciences; Estados Unidos. Fil: Palefsky, Joel M. University of California San Francisco. Department of Medicine; Estados Unidos. Fil: Giovannelli, Lucía. Azienda Ospedaliera Universitaria Policlinico P. Giaccone. Dipartimento di Scienze per la Promozione della Salute. Sezione di Microbiologia; Italia. Fil: Coutlée, Francois. Centre Hospitalier de l'Université de Montréal. Département de Microbiologie et Infectiologie; Canadá. Fil: Hibbitts, Samantha. Cardiff University. School of Medicine. HPV Research Group, Cancer and Genetics Research Institute; Reino Unido. Fil: Konno, Ryo. Jichi Medical University. Saitama Medical Center. Department of Obstetrics and Gynecology; Japón. Fil: Settheetham-Ishida, Wannapa. Khon Kaen University. Faculty of Medicine. Department of Physiology; Tailandia. Fil: Chu, Tang-Yuan. Tzu Chi University. Buddhist Tzu Chi General Hospital. Institute of Medical Sciences. Department of Obstetrics and Gynaecology; Taiwan. Fil: Ferrera, Annabelle. Universidad Nacional Autónoma de Honduras. Science Faculty. School of Microbiology; Honduras. Fil: Picconi, María Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento Virología. Servicio Virus Oncogénicos; Argentina. Fil: De Marco, Federico.The Regina Elena National Cancer Institute. Laboratory of Virology; Italia. Fil: Woo, Yin-Ling. University of Malaya. Department of Obstetrics and Gynaecology; Malasia. Fil: Raiol, Tainá. University of Brasilia. Institute of Biology. Department of Cellular Biology; Brasil. Fil: Piña-Sánchez, Patricia. Hospital de Oncología. Unidad de Investigación Médica en Enfermedades Oncológicas; México. Fil: Bae, Jeong-Hoon. The Catholic University of Korea. Seoul St. Mary's Hospital. Department of Obstetrics and Gynecology; Corea del Sur. Fil: Wong, Martin C S. The Chinese University of Hong Kong. Faculty of Medicine. School of Public Health and Primary Care; China. Fil: Chirenje, Mike Z. University of Zimbabwe. Department of Obstetrics and Gynecology; Zimbabue. Fil: Magure, Tsitsi. University of Zimbabwe. Department of Obstetrics and Gynecology; Zimbabue. Fil: Moscicki, Anna-Barbara. University of California San Francisco. Helen Diller Family Comprehensive Cancer Center; Estados Unidos. Fil: Fiander, Alison N. Cardiff University. School of Medicine. HPV Research Group, Cancer and Genetics Research Institute; Reino Unido. Fil: Capra, Giuseppina. Azienda Ospedaliera Universitaria Policlinico P. Giaccone. Dipartimento di Scienze per la Promozione della Salute. Sezione di Microbiologia; Italia. Fil: Young Ki, Eun. The Catholic University of Korea. Seoul St. Mary's Hospital. Department of Obstetrics and Gynecology; Corea del Sur. Fil: Tan, Yi. The Chinese University of Hong Kong. Faculty of Medicine. Stanley Ho Centre for Emerging Infectious Diseases; China. Fil: Chen, Zigui. Albert Einstein College of Medicine; Estados Unidos. Fil: Burk, Robert D. Albert Einstein College of Medicine; Estados Unidos. Fil: Chan, Martin C W. The Chinese University of Hong Kong. Faculty of Medicine. Department of Microbiology; China. Fil: Cheung, Tak-Hong. Prince of Wales Hospital. Department of Obstetrics and Gynaecology; China. Fil: Pim, David. International Centre for Genetic Engineering and Biotechnology; Italia. Fil: Banks, Lawrence. International Centre for Genetic Engineering and Biotechnology; Italia. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/2014 | DOI: | 10.1002/ijc.27932 | Rights: | Open Access |
Appears in Collections: | Publicaciones INEI |
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