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Title: | Genetic diversity of G3 rotavirus strains circulating in Argentina during 1998-2012 assessed by full genome analyses | Authors: | Degiuseppe, Juan Ignacio Parra, Gabriel Ignacio Stupka, Juan Andrés |
Keywords: | Secuencia de Aminoácidos;Antígenos Virales;Argentina;Proteínas de la Cápside;Evolución Molecular;Secuenciación de Nucleótidos de Alto Rendimiento;Humanos;Epidemiología Molecular;Datos de Secuencia Molecular;Rotavirus;Infecciones por Rotavirus;Brotes de Enfermedades;Variación Genética;Genoma Viral;Genotipo;Filogenia | Issue Date: | 22-Oct-2014 | Publisher: | Public Library of Science | Project: | datasets | Journal: | PloS one | Abstract: | Seasonal shifts in the predominant strains and the periodic emergence of new strains are epidemiological features of human rotaviruses. After the sporadic detection in two samples in 1998, G3P[8] strains reemerged as the predominant rotavirus during 2008-2009 in Argentina. Notably, in 2011 6.3% (37/587) of samples presented the G3P[6] genotypes, which coincided with the recent detection of G3P[6] and G2P[6] strains in South America and Europe. Analyses of the 11 gene segments of four G3P[8] and two G3P[6] strains revealed that G3P[8] strains detected a decade apart (1998 and 2009) presented minor differences, while the G3P[6] strains presented a complete different genomic constellation albeit showing a similar VP7 gene. This study provides insights in the dynamics and evolution of one of the genotypes with the wider range of hosts and inter-species transmission potential. |
Description: | Fil: Degiuseppe, Juan Ignacio. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Laboratorio de Gastroenteritis Virales; Argentina. Fil: Parra, Gabriel Ignacio. Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud; Paraguay. Fil: Stupka, Juan Andrés. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Laboratorio de Gastroenteritis Virales; Argentina. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1979 | DOI: | 10.1371/journal.pone.0110341 | Rights: | Open Access |
Appears in Collections: | Publicaciones INEI |
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File | Description | Size | Format | |
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PLoS One_2014_22_9_10_p1-p7.pdf | Artículo en inglés | 1.25 MB | Adobe PDF | View/Open |
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