Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/1949
Title: Molecular characterization of invasive serogroup Y Neisseria meningitidis strains isolated in the Latin America region
Authors: Abad, Raquel 
Agudelo, Clara Inés 
Brandileone, María Cristina 
Chanto, Grettel 
Gabastou, Jean-Marc 
Hormazabal, Juan Carlos 
O Gorla, M Cecilia 
Maldonado, Aurora 
Moreno, Jaime 
Muros-Le Rouzic, Erwan 
Lersch, Robert 
Regueira, Mabel 
Salcedo, Celia 
Sorhouet Pereira, Cecilia 
Vázquez, Julio A. 
Keywords: Neisseria meningitidis Serogrupo Y;Neisseria meningitidis;Infecciones Meningocócicas
Issue Date: Aug-2009
Journal: Journal of infection 
Abstract: 
Objectives: To improve the understanding of serogroup Y invasive meningococcal disease (IMD) in Latin America, particularly IMD molecular epidemiology; 166 Y serogroup isolates received at the National Reference Laboratories of Argentina, Brazil, Chile, Colombia, and Costa Rica during 2000-2006 were characterized by their molecular markers.

Methods: This analysis included serological assays to determine serogroup/serotype/serosubtype, DNA sequencing and genotyping of the porB and/or porA genes, multilocus sequence typing (MLST) and fetA allele determination.

Results: Sixteen different antigenic combinations were observed. Sixty-two (37.3%) isolates were NT:P1.5 and 36 (21.7%) isolates were 14:NST. Thirty-two different STs appeared, but 3 STs (ST-1624, ST-23, and ST-5770) accounted for 69.9% (116) of the strains. Most of the IMD isolates belonged to the ST-23, ST-167 clonal complexes or the group composed by ST-5770 and related STs.

Conclusions: Isolates obtained in Colombia and Costa Rica were similar to that of the United States, in that most sequence types belonged to the ST-23 clonal complex. IMD isolates found in Argentina appear to be the result of an independent event and did not spread from nearby countries, being the sequence type ST-1624 (ST-167 clonal complex) the most frequently found. We were unable to correlate an antigenic shift of outer membrane proteins with an increase of serogroup Y meningococcal cases in our collection of isolates.
Description: 
Fil: Abad, Raquel. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.

Fil: Agudelo, Clara Inés. Instituto Nacional de Salud (INS). Microbiología; Colombia.

Fil: Brandileone, María Cristina. Adolfo Lutz Institute. Bacteriology Branch; Brasil.

Fil: Chanto, Grettel. Centro Nacional de Referencia en Bacteriología (INCIENSA); Costa Rica.

Fil: Gabastou, Jean-Marc. Pan American Health Organization (PAHO)/World Health Organization (WHO). Vacunas y Tecnologías de Salud. Unidad de Medicamentos Esenciales; Ecuador.

Fil: Hormazabal, Juan Carlos. Instituto de Salud Pública (ISP). Bacteriología; Chile.

Fil: O Gorla, M Cecilia. Adolfo Lutz Institute. Bacteriology Branch; Brasil.

Fil: Maldonado, Aurora. Instituto de Salud Pública (ISP). Bacteriología; Chile.

Fil: Moreno, Jaime. Instituto Nacional de Salud (INS). Microbiología; Colombia.

Fil: Muros-Le Rouzic, Erwan. Sanofi-Pasteur. Global Scientific and Medical Affairs; Francia.

Fil: Lersch, Robert. Sanofi-Pasteur. Global Scientific and Medical Affairs; Francia.

Fil: Regueira, Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.

Fil: Salcedo, Celia. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.

Fil: Sorhouet, Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.

Fil: Vázquez, Julio A. Instituto de Salud Carlos III. Centro Nacional de Microbiología. Reference Laboratory for Meningococci; España.
URI: http://sgc.anlis.gob.ar/handle/123456789/1949
ISSN: 0163-4453
DOI: 10.1016/j.jinf.2009.06.001
Rights: Closed Access
Appears in Collections:Publicaciones INEI

Show full item record

Page view(s)

38
checked on Mar 28, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.