Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/1942
Title: | Relationship between hematopoietic growth factors levels and hematological parameters in Argentine hemorrhagic fever | Authors: | Marta, R F Enria, Delia Molina, Fabiana |
Keywords: | Fiebre Hemorrágica Americana | Issue Date: | May-2000 | Publisher: | Wiley | Journal: | American journal of hematology | Abstract: | Argentine hemorrhagic fever (AHF) is a viral disease caused by Junin virus and characterized by hematologic and neurological involvement. The main hematologic features are leukopenia, thrombocytopenia, and bone marrow hypoplasia. Hematopoietic growth factors serum levels were measured by ELISA technique in forty-eight patients with confirmed diagnosis of AHF. Patients were classified according to the clinical picture in 15 severe (SCF), 17 moderate (MoCF), and 16 mild (MiCF) cases. Erythropoietin levels were decreased in 28 of 45 patients and raised in 4 SCF patients. Twenty-four of 38 patients had high G-CSF levels at admittance in accordance with clinical picture severity, while IL-3, GM-CSF, and TGF-beta were normal in most cases. A direct correlation was found between G-CSF and TNF-alpha levels. Thrombopoietin levels were found to be raised in 19 of 21 patients. In conclusion, the low levels of Epo may contribute to the severe bone marrow erythroblastopenia described in AHF patients, while G-CSF seems to be a marker of illness severity. |
Description: | Fil: Marta, R F. Sección Hematología Investigación, Instituto de Investigaciones Médicas Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires; Argentina. Fil. Enria, Delia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina. Fil: Molina, Fabiana.Sección Hematología Investigación, Instituto de Investigaciones Médicas Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires; Argentina. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1942 | ISSN: | 0361-8609 | DOI: | 10.1002/(sici)1096-8652(200005)64:1<1::aid-ajh1>3.0.co;2-f | Rights: | Open Access |
Appears in Collections: | Publicaciones INEVH |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
American Journal of Hematology_ 2000_64(1)_1-6.pdf | Artículo en inglés | 143.41 kB | Adobe PDF | View/Open |
Page view(s)
43
checked on Oct 16, 2024
Download(s)
4
checked on Oct 16, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.