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http://sgc.anlis.gob.ar/handle/123456789/1939| Title: | Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT) | Authors: | Marin-Neto, José Antônio Rassi, Anis Morillo, Carlos A Avezum, Álvaro Connolly, Stuart J Sosa-Estani, Sergio Rosas, Fernando Yusuf, Salim |
Keywords: | Cardiomiopatía Chagásica;Trypanosoma cruzi | Issue Date: | Jul-2008 | Publisher: | Elsevier | Journal: | American Heart Journal | Abstract: | Benznidazole is effective for treating acute and chronic (recently acquired) Trypanosoma cruzi infection (Chagas' disease). Recent data indicate that parasite persistence plays a pivotal role in the pathogenesis of chronic Chagas' cardiomyopathy. However, the efficacy of trypanocidal therapy in preventing clinical complications in patients with preexisting cardiac disease is unknown. |
Description: | Fil: Marin-Neto, José Antônio. Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirão Preto, Sao Paulo; Brasil. Fil: Rassi, Anis. Anis Rassi Hospital, Goiania; Brasil. Fil: Morillo, Carlos A. McMaster University, Population Health Research Institute HGH-McMaster Clinic, East Hamilton, Ontario; Canada. Fil: Avezum, Álvaro. Instituto Dante Pazzanese de Cardiologia, Sao Paulo; Brasil. Fil: Connolly, Stuart J. McMaster University, Population Health Research Institute HGH-McMaster Clinic, East Hamilton, Ontario; Canada. Fil: Sosa-Estani, Sergio. ANLIS Dr.C.G.Malbrán. Centro Nacional de Diagnóstico e Investigación en Endemo-Epidemias; Argentina. Fil: Rosas, Fernando. Clinica A. Saio, Bogota; Colombia. Fil: Yusuf, Salim. McMaster University, Population Health Research Institute HGH-McMaster Clinic, East Hamilton, Ontario; Canada. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1939 | ISSN: | 0002-8703 | DOI: | 10.1016/j.ahj.2008.04.001 | Rights: | Closed Access |
| Appears in Collections: | Publicaciones CeNDIE |
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