Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/1920
Title: Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates
Authors: Faccone, Diego 
Veliz, Omar 
Corso, Alejandra 
Noguera, Martín Ezequiel 
Martínez, Melina 
Payes, Cristian 
Semorile, Liliana 
Maffía, Paulo Cesar 
Keywords: Dicroismo Circular;Péptidos Catiónicos Antimicrobianos;Antibacterianos;Resistencia a Medicamentos
Issue Date: Jan-2014
Journal: European journal of medicinal chemistry 
Abstract: 
Antibiotic resistance is one of the main problems concerning public health or clinical practice. Antimicrobial peptides appear as good candidates for the development of new therapeutic drugs. In this study we de novo designed a group of cationic antimicrobial peptides, analyzed its physicochemical properties, including its structure by circular dichroism and studied its antimicrobial properties against a panel of clinical isolates expressing different mechanisms of resistance. Three cationic alpha helical peptides exhibited antimicrobial activity comparable to, or even better than the comparator omiganan (MBI-226).
Description: 
Fil: Faccone, Diego. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Antimicrobianos; Argentina.

Fil: Veliz, Omar. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Antimicrobianos; Argentina.

Fil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Antimicrobianos; Argentina.

Fil: Noguera, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.

Fil: Martínez, Melina. Universidad Nacional de Quilmes. Laboratorio de Microbiología Molecular; Argentina.

Fil: Payes, Cristian. Universidad Nacional de Quilmes. Laboratorio de Microbiología Molecular; Argentina.

Fil: Semorile, Liliana. Universidad Nacional de Quilmes. Laboratorio de Microbiología Molecular; Argentina.

Fil: Maffía, Paulo Cesar. Universidad Nacional de Quilmes. Laboratorio de Microbiología Molecular; Argentina.
URI: http://sgc.anlis.gob.ar/handle/123456789/1920
DOI: 10.1016/j.ejmech.2013.10.065
Rights: Closed Access
Appears in Collections:Publicaciones INEI

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