Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/1864
DC Field | Value | Language |
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dc.contributor.author | Fellner, María Dolores | es |
dc.contributor.author | Durand, Karina A | es |
dc.contributor.author | Solernou, Veronica | es |
dc.contributor.author | Bosaleh, Andrea | es |
dc.contributor.author | Balbarrey, Ziomara | es |
dc.contributor.author | García de Dávila, María T | es |
dc.contributor.author | Rodriguez, Marcelo | es |
dc.contributor.author | Irazu, Lucía | es |
dc.contributor.author | Alonio, Lidia V. | es |
dc.contributor.author | Picconi, María Alejandra | es |
dc.date.accessioned | 2020-12-10T14:28:34Z | - |
dc.date.available | 2020-12-10T14:28:34Z | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 0325-7541 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/1864 | - |
dc.description | Fil: Fellner, María Dolores. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Durand, Karina A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Solernou, Veronica. "Prof. Dr. Juan. P. Garrahan" National Pediatrics Hospital. Pathology Service; Argentina. | es |
dc.description | Fil: Bosaleh, Andrea. "Prof. Dr. Juan. P. Garrahan" National Pediatrics Hospital. Pathology Service; Argentina. | es |
dc.description | Fil: Balbarrey, Ziomara. "Prof. Dr. Juan. P. Garrahan" National Pediatrics Hospital. Pathology Service; Argentina. | es |
dc.description | Fil: García de Dávila, María T. "Prof. Dr. Juan. P. Garrahan" National Pediatrics Hospital. Pathology Service; Argentina. | es |
dc.description | Fil: Rodríguez, Marcelo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Irazu, Lucía. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Alonio, Lidia V. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description | Fil: Picconi, María A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | es |
dc.description.abstract | High levels of circulating EBV load are used as a marker of post-transplant lymphoproliferative disorders (PTLD). There is no consensus regarding the threshold level indicative of an increase in peripheral EBV DNA. The aim of the study was to clinically validate a developed EBV quantification assay for early PTLD detection. Transversal study: paired peripheral blood mononuclear cells (PBMC), plasma and oropharyngeal lymphoid tissue (OLT) from children undergoing a solid organ transplant with (n=58) and without (n=47) PTLD. Retrospective follow-up: 71 paired PBMC and plasma from recipients with (n=6) and without (n=6) PTLD history. EBV load was determined by real-time PCR. The diagnostic ability to detect all PTLD (categories 1-4), advanced PTLD (categories 2-4) or neoplastic PTLD (categories 3 and 4) was estimated by analyzing the test performance at different cut-off values or with a load variation greater than 0.5log units. The higher diagnostic performance for identifying all, advanced or neoplastic PTLD, was achieved with cut-off values of 1.08; 1.60 and 2.47log EBVgEq/10(5) PBMC or 2.30; 2.60; 4.47loggEq/10(5) OLT cells, respectively. EBV DNA detection in plasma showed high specificity but low (all categories) or high (advanced/neoplastic categories) sensitivity for PTLD identification. Diagnostic performance was greater when: (1) a load variation in PBMC or plasma was identified; (2) combining the measure of EBV load in PBMC and plasma. The best diagnostic ability to identify early PTLD stages was achieved by monitoring EBV load in PBMC and plasma simultaneously; an algorithm was proposed. | es |
dc.format | - | |
dc.language.iso | en | es |
dc.publisher | Asociación Argentina de Microbiología | es |
dc.relation | datasets | es |
dc.relation.ispartof | Revista Argentina de microbiologia | es |
dc.rights | Open Access | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Revista Argentina de Microbiología 2016; 48(2):110-118 | - |
dc.subject | Carga viral | es |
dc.subject | Linfoma | es |
dc.subject | Reacción en Cadena en Tiempo Real de la Polimerasa | es |
dc.subject | Herpesvirus Humano 4 | es |
dc.subject | Niño | es |
dc.subject | Preescolar | es |
dc.subject | Estudios Transversales | es |
dc.subject | ADN Viral | es |
dc.subject | Detección Precoz del Cáncer | es |
dc.subject | Infecciones por Virus de Epstein-Barr | es |
dc.subject | Estudios de Seguimiento | es |
dc.subject | Humanos | es |
dc.subject | Huésped Inmunocomprometido | es |
dc.subject | Lactante | es |
dc.subject | Leucocitos Mononucleares | es |
dc.subject | Tejido Linfoide | es |
dc.subject | Linfoma | es |
dc.subject | Trastornos Linfoproliferativos | es |
dc.subject | Complicaciones Posoperatorias | es |
dc.subject | Estudios Retrospectivos | es |
dc.subject | Viremia | es |
dc.subject | Trasplante de Corazón | es |
dc.subject | Trasplante de Riñón | es |
dc.subject | Trasplante de Hígado | es |
dc.title | Epstein-Barr virus load in transplant patients: Early detection of post-transplant lymphoproliferative disorders | es |
dc.title.alternative | Carga de virus Epstein-Barr en pacientes trasplantados: detección temprana de desórdenes linfoproliferativos postrasplante | es |
dc.type | Artículo | es |
dc.rights.license | Creative Commons Attribution 4.0 International License | - |
dc.identifier.doi | 10.1016/j.ram.2016.02.006 | - |
anlis.essnrd | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Artículo | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.dept | Departamento de Parasitología | - |
crisitem.author.dept | Servicio Desarrollo de Reactivos | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.dept | Departamento de Parasitología | - |
crisitem.author.dept | Servicio Desarrollo de Reactivos | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.dept | Departamento de Virología | - |
crisitem.author.dept | Servicio Virus Oncogénicos | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.parentorg | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.parentorg | Departamento de Parasitología | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.parentorg | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.parentorg | Departamento de Parasitología | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.parentorg | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
crisitem.author.parentorg | Departamento de Virología | - |
Appears in Collections: | Publicaciones INEI |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Revista Argentina de Microbiología_2016_48_2_p110-p118.pdf | Artículo en inglés | 948.45 kB | Adobe PDF | View/Open |
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