Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/1840
DC Field | Value | Language |
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dc.contributor.author | Antúnez, María Inés | es |
dc.contributor.author | Cardoni, Rita L. | es |
dc.date.accessioned | 2020-12-06T00:42:11Z | - |
dc.date.available | 2020-12-06T00:42:11Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0014-4894 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/1840 | - |
dc.description | Fil: Antúnez, María Inés. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. | es |
dc.description | Fil: Cardoni, Rita L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. | es |
dc.description.abstract | T and NK cells play a key role in resistance to Trypanosoma cruzi infections, mainly through IFN-gamma production. The expression of T and NK cells surface markers was studied in NWNA spleen cells of resistant C3H and susceptible BALB/c mice that release IFN-gamma in the early and late acute infection, respectively. In the progressively enlarged spleens, we found: (a) an increased percentage and number of NK blast cells as early as at 2 days post-infection (pi), (b) an enrichment of T and NK cells, in both the total and blast populations, during the late acute phase. At 17 days pi, there was also an accumulation of TCR- alphabeta+DX5+, NKT cells, mainly in resistant mice. At 21 days pi, the enrichment of NK cells ceased, while spleen cells and the T cell compartment continued their expansion. In the chronic stage, TCR-alphabeta+ blasts were expanded in both mouse strains, but NK blasts increased only in BALB/c that, unlike C3H mice, release IFN-gamma. As T and NK cell proliferation is not always associated to IFN-gamma release the experimental downregulation of their expansion to avoid tissue damage could be explored. | es |
dc.language.iso | en | es |
dc.relation.ispartof | Experimental parasitology | es |
dc.rights | Closed Access | - |
dc.source | Experimental Parasitology 2004;106(3-4):85-94. | - |
dc.subject | Trypanosoma cruzi | es |
dc.title | Trypanosoma cruzi: the expansion of NK, T, and NKT cells in the experimental infection | es |
dc.type | Artículo | es |
dc.identifier.doi | 10.1016/j.exppara.2004.03.008 | - |
anlis.essnrd | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | Artículo | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
Appears in Collections: | Publicaciones INP |
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