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Title: | Emergence of resistance to ciprofloxacin in Neisseria meningitidis in Brazil | Authors: | Gorla, María Cecilia Cassiolato, Ana Paula Pinhata, Juliana Maira Watanabe de Moraes, Camile Corso, Alejandra Gagetti, Paula Lemos, Ana Paula |
Keywords: | Ciprofloxacino;Antibacterianos;Brasil;Girasa de ADN;Topoisomerasa de ADN IV;Farmacorresistencia Bacteriana;Fluoroquinolonas;Humanos;Infecciones Meningocócicas;Pruebas de Sensibilidad Microbiana;Tipificación de Secuencias Multilocus;Mutación;Neisseria gonorrhoeae;Neisseria meningitidis;Quinolonas | Issue Date: | Mar-2018 | Publisher: | Microbiology Society | Project: | datasets | Journal: | Journal of medical microbiology | Abstract: | To prevent secondary invasive meningococcal disease (IMD) cases and outbreaks, antimicrobial prophylaxis of high-risk contacts is indicated. This study reports two ciprofloxacin-resistant Neisseria meningitidis strains in Brazil. The 3523 N. meningitidis isolates collected throughout Brazil from 2009 to 2016 were evaluated for antimicrobial resistance. Meningococcal isolates showing minimal inhibitory concentrations, MICs≥0.125µg ml-1 to ciprofloxacin, were analysed to determine the presence of mutations in the quinolone resistance-determining regions (QRDRs) of gyrA and parC genes. Two ciprofloxacin-resistant N. meningitidis isolates were found, both presenting a single mutation in the quinolone resistance-determining region of the gyrA gene. These results confirmed that ciprofloxacin is still a first-line drug for chemoprophylaxis. However, we highlight the importance of continued surveillance to monitor the trends of N. meningitidis susceptibility profiles to the antimicrobials recommended for chemoprophylaxis and IMD treatment. |
Description: | Fil: Gorla, Maria Cecília. Adolfo Lutz Institute. Bacteriology Department; Brasil. Fil: Cassiolato, Ana Paula. Adolfo Lutz Institute. Bacteriology Department; Brasil. Fil: Pinhata, Juliana Maira Watanabe. Adolfo Lutz Institute. Bacteriology Department; Brasil. Fil: de Moraes, Camile. Ministry of Health. Secretariat of Health Surveillance; Brasil. Fil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. Fil: Gagetti, Paula. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. Fil: Lemos, Ana Paula. Adolfo Lutz Institute. Bacteriology Department; Brasil. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1814 | DOI: | 10.1099/jmm.0.000685 | Rights: | Open Access |
Appears in Collections: | Publicaciones INEI |
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Journal of medica microbiology_2018_67_p286-p288.pdf | Artículo en inglés | 112.07 kB | Adobe PDF | View/Open |
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