Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/1810
Title: IgG subclasses in human immune response to wild and attenuated (vaccine) Junin virus infection
Authors: Saavedra, María del Carmen 
Sottosanti, Josefa María 
Riera, Laura 
Ambrosio, Ana M. 
Keywords: Adolescente;Adulto;Anticuerpos Antivirales;Infecciones por Arenaviridae;Femenino;Fiebre Hemorrágica Americana;Humanos;Inmunoglobulina G;Virus Junin;Masculino;Persona de Mediana Edad;Vaccination;Vacunas Atenuadas;Vacunas Virales
Issue Date: Mar-2003
Publisher: Wiley
Wiley-Liss
Project: datasets
Journal: Journal of medical virology 
Abstract: 
Different proportions of IgG subclasses have previously been reported to distinguish the immune response elicited by primary and recurrent viral infections, as well as viral vaccines. The goal of this study was to study the IgG subclasses composition in the immune response of patients with Argentine hemorrhagic fever, and vaccinees with Candid #1 strain of Junin virus. Twenty-four individuals inoculated with Candid #1 vaccine and 67 patients with Argentine hemorrhagic fever were studied. Blood samples were drawn at 30, 60, and/or 180 days post-inoculation with Candid #1 and 30, 60, and 90 days after clinical onset of the disease. Specific anti-Junin virus IgG subclasses were titrated with specific human monoclonal antibody fluorescence isothiocyanate conjugate (FITC) by immunofluorescent assay (IFA). IgG(1) anti-Junin virus was found in every subject studied and IgG(3) was also detected in some patients with a severe form of Argentine hemorrhagic fever. IgG(2) and IgG(4) were not detected in any serum sample studied. The mean titer of specific IgG(1) in vaccinees was significantly lower than in patients with Argentine hemorrhagic fever (P < 0.05), but no difference was found between mild and severe cases of the disease (P > 0.05). The results of this study demonstrated a central role of IgG(1) in human recovery from infection with every strain of Junin virus, an observation stressed by the immune response to Candid #1 vaccine, which resulted in no difference in IgG subclasses composition from that found in mild cases of Argentine hemorrhagic fever.
Description: 
Fil: Saavedra, María del Carmen. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.

Fil: Sottosanti, Josefa María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.

Fil: Riera, Laura. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.

Fil: Ambrosio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
URI: http://sgc.anlis.gob.ar/handle/123456789/1810
ISSN: 0146-6615
DOI: 10.1002/jmv.10308
Rights: Open Access
Appears in Collections:Publicaciones INEVH

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