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Título: | Genomics of the Argentinian cholera epidemic elucidate the contrasting dynamics of epidemic and endemic Vibrio cholerae | Autor(es): | Dorman, Matthew J Domman, Daryl Poklépovich, Tomás Javier Tolley, Charlotte Zolezzi, Gisela Kane, Leanne Viñas, María R. Panagópulo, Marcela Moroni, Miriam Binsztein, Norma Caffer, María Inés Clare, Simon Dougan, Gordon Salmond, George P C Parkhill, Julian Campos, Josefina Thomson, Nicholas R |
Palavras-chave: | Bacteriología;Patógenos Transmitidos por la Sangre;Infecciones Bacterianas | Data do documento: | 1-Out-2020 | Jornal: | Nature communications | Resumo: | In order to control and eradicate epidemic cholera, we need to understand how epidemics begin, how they spread, and how they decline and eventually end. This requires extensive sampling of epidemic disease over time, alongside the background of endemic disease that may exist concurrently with the epidemic. The unique circumstances surrounding the Argentinian cholera epidemic of 1992-1998 presented an opportunity to do this. Here, we use 490 Argentinian V. cholerae genome sequences to characterise the variation within, and between, epidemic and endemic V. cholerae. We show that, during the 1992-1998 cholera epidemic, the invariant epidemic clone co-existed alongside highly diverse members of the Vibrio cholerae species in Argentina, and we contrast the clonality of epidemic V. cholerae with the background diversity of local endemic bacteria. Our findings refine and add nuance to our genomic definitions of epidemic and endemic cholera, and are of direct relevance to controlling current and future cholera epidemics. |
Descrição: | Fil: Dorman, Matthew J. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido. Fil: Domman, Daryl. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido. Fil: Poklepovich, Tomás. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. Fil: Tolley, Charlotte. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido. Fil: Zolezzi, Gisella. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. Fil: Kane, Leanne. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido. Fil: Viñas, María Rosa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. Fil: Panagópulo, Marcela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. Fil: Moroni, Miriam. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. Fil: Binsztein, Norma. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. Fil: Caffer, María Inés. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. Fil: Clare, Simon. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido. Fil: Dougan, Gordon. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido. Fil: Salmond, George P. C. University of Cambridge. Department of Biochemistry, Cambridge; Reino Unido. Fil: Parkhill, Julian. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido. Fil: Campos, Josefina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. Fil: Thomson, Nicholas R. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1775 | ISSN: | 2041-1723 | DOI: | 10.1038/s41467-020-18647-7 | Direitos: | Open Access Creative Commons Attribution 4.0 International License |
Aparece nas Coleções: | Publicaciones INEI |
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naturecommunications_2020_11-1-4918.pdf | 1.83 MB | Adobe PDF | Ver/Aberto |
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