Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/1740
Title: Effective population size differences in Calomys musculinus, the host of Junín Virus: their relationship with the epidemiological history of Argentine Hemorrhagic fever
Authors: Chiappero, Marina B 
Piacenza, María Florencia 
Provensal, María Cecilia 
Calderón, Gladys 
Gardenal, Cristina N 
Polop, Jaime J 
Keywords: Animales;Argentina;Reservorios de Enfermedades;Enfermedades Endémicas;Flujo Génico;Variación Genética;Genética de Población;Fiebre Hemorrágica Americana;Humanos;Incidencia;Virus Junin;Densidad de Población;Sigmodontinae
Issue Date: Aug-2018
Publisher: American Society of Tropical Medicine and Hygiene
Project: datasets
Journal: The American journal of tropical medicine and hygiene 
Abstract: 
Argentine hemorrhagic fever (AHF) is a serious endemic disease in Argentina, produced by Junín virus, whose host is the Sigmodontinae rodent Calomys musculinus. Within the endemic area, human incidence and proportion of infected rodents remains high for 5-10 years after the first appearance of the disease (epidemic [E] zone) and then gradually declines to sporadic cases (historic [H] zone). We tested the hypothesis that host populations within the E zone are large and well connected by gene flow, facilitating the transmission and maintenance of the virus, whereas those in the H and nonendemic (NE) zones are small and isolated, with the opposite effect. We estimated parameters affected by levels of gene flow and population size in 14 populations of C. musculinus: population effective size (Ne), genetic variability, and mean relatedness. Our hypothesis was not supported: the lowest levels of variability and of Ne and the highest genetic relatedness among individuals were found in the H zone. Populations from the NE zone displayed opposite results, whereas those in the E zone showed intermediate values. If we consider that populations are first NE, then E, and finally H, a correlative decrease in Ne was observed. Chronically infected females have a low reproductive success. We propose that this would lower Ne because each cohort would originate from a fraction of females of the previous generation, and affect other factors such as proportion of individuals that develop acute infection, probability of viral transmission, and evolution of virulence, which would explain, at least partly, the changing incidence of AHF.
Description: 
Fil: Chiappero, Marina B. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Diversidad y Ecología Animal; Argentina.

Fil: Piacenza, María Florencia. Universidad Nacional de Río Cuarto. Departamento de Ciencias Naturales; Argentina.

Fil: Provensal, María Cecilia. Universidad Nacional de Río Cuarto. Departamento de Ciencias Naturales; Argentina.

Fil: Calderón, Gladys E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.

Fil: Gardenal, Cristina N. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Diversidad y Ecología Animal; Argentina.

Fil: Polop, Jaime J. Universidad Nacional de Río Cuarto. Departamento de Ciencias Naturales; Argentina.
URI: http://sgc.anlis.gob.ar/handle/123456789/1740
DOI: 10.4269/ajtmh.17-0838
Rights: Open Access
Appears in Collections:Publicaciones INEVH

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