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Title: | Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections | Authors: | Abascal, Estefanía Herranz, Marta Acosta, Fermín Agapito, Juan Cabibbe, Andrea M Monteserin, Johana Ruiz Serrano, María Jesús Gijón, Paloma Fernández-González, Francisco Lozano, Nuria Chiner-Oms, Álvaro Cáceres, Tatiana Pintado, Pilar Gómez Acín, Enrique Valencia, Eddy Muñoz, Patricia Comas, Iñaki Cirillo, Daniela M Ritacco, Viviana Gotuzzo, Eduardo Garcia de Viedma, Dario |
Keywords: | Antibióticos Antituberculosos | Issue Date: | 2020 | Journal: | Scientific reports | Abstract: | It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR-clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002-5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection. |
Description: | Fil: Abascal, Estefanía. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España Fil: Herranz, Marta. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España Fil: Acosta, Fermín. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España Fil: Agapito, Juan. TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima; Peru. Fil: Cabibbe, Andrea M. Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan; Italia. Fil: Monteserín, Johana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Epidemiología; Argentina. Fil: Ruiz Serrano, María Jesús. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España. Fil: Gijón, Paloma. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España. Fil: Fernández-González, Francisco. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España. Fil: Lozano, Nuria. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España. Fil: Chiner-Oms, Álvaro. Unidad Mixta Genómica y Salud, Centro Superior de Investigación en Salud Pública (FISABIO)-Universitat de València; España. Fil: Cáceres, Tatiana. TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima; Peru. Fil: Gómez Pintado, Pilar. General Subdirection of Penitentiary Health - Penitentiary Institutions - Ministry of Interior of Spain; España. Fil: Acín, Enrique. General Subdirection of Penitentiary Health - Penitentiary Institutions - Ministry of Interior of Spain; España. Fil: Muñoz, Patricia. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España Fil: Comas, Iñaki. Instituto de Biomedicina de Valencia (IBV) Consejo Superior de Investigaciones Científicas (CSIC); España. Fil: Cirillo, Daniela M. Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan; Italia. Fil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Epidemiología; Argentina. Fil: Gotuzzo, Eduardo. TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima; Peru. Fil: García de Viedma, Dario. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1727 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-020-59373-w | Rights: | Open Access Creative Commons Attribution 4.0 International License |
Appears in Collections: | Publicaciones INEI |
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41598_2020_Article_59373.pdf | Artículo en inglés | 1.42 MB | Adobe PDF | View/Open |
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