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Title: | Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings | Authors: | Feasey, Nicholas A Hadfield, James Keddy, Karen H Dallman, Timothy J Jacobs, Jan Deng, Xiangyu Wigley, Paul Barquist, Lars Langridge, Gemma C Feltwell, Theresa Harris, Simon R Mather, Alison E Fookes, Maria Aslett, Martin Msefula, Chisomo Kariuki, Samuel Maclennan, Calman A Onsare, Robert S Weill, François-Xavier Le Hello, Simon Smith, Anthony M McClelland, Michael Desai, Prerak Parry, Christopher M Cheesbrough, John French, Neil Campos, Josefina Chabalgoity, Jose A Betancor, Laura Hopkins, Katie L Nair, Satheesh Humphrey, Tom J Lunguya, Octavie Cogan, Tristan A Tapia, Milagritos D Sow, Samba O Tennant, Sharon M. Bornstein, Kristin Levine, Myron M Lacharme-Lora, Lizeth Everett, Dean B Kingsley, Robert A Parkhill, Julian Heyderman, Robert S Dougan, Gordon Gordon, Melita A Thomson, Nicholas R |
Keywords: | Adaptación Biológica;África del Sur del Sahara;Animales;Pollos;Enterocolitis;Epidemias;Genoma Bacteriano;Humanos;Renta;Plásmidos;Enfermedades de las Aves de Corral;Infecciones por Salmonella;Análisis de Secuencia de ADN;Salmonella enteritidis | Issue Date: | Oct-2016 | Publisher: | Nature Research | Journal: | Nature genetics | Abstract: | An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa. |
Description: | Fil: Feasey, Nicholas A. Liverpool School of Tropical Medicine; Reino Unido. Fil: Hadfield, James. Wellcome Trust Sanger Institute; Reino Unido. Fil: Keddy, Karen H. National Institute for Communicable Diseases. Centre for Enteric Diseases; Sudáfrica. Fil: Dallman, Timothy J. Public Health England. Gastrointestinal Bacteria Reference Unit; Reino Unido. Fil: Jacobs, Jan. Institute of Tropical Medicine; Bélgica. Fil: Deng, Xiangyu. University of Georgia. Center for Food Safety, Department of Food Science and Technology; Estados Unidos. Fil: Wigley, Paul. University of Liverpool. Institute of Infection and Global Health; Reino Unido. Fil: Barquist, Lars. University of Würzburg. Institute for Molecular Infection Biology; Alemania. Fil: Langridge, Gemma C. Wellcome Trust Sanger Institute; Reino Unido. Fil: Feltwell, Theresa. Wellcome Trust Sanger Institute; Reino Unido. Fil: Harris, Simon R. Wellcome Trust Sanger Institute; Reino Unido. Fil: Mather, Alison E. Wellcome Trust Sanger Institute; Reino Unido. Fil: Fookes, Maria. Wellcome Trust Sanger Institute; Reino Unido. Fil: Aslett, Martin. Wellcome Trust Sanger Institute; Reino Unido. Fil: Msefula, Chisomo. University of Malawi. College of Medicine. Malawi Liverpool Wellcome Trust Clinical Research Programme; Malaui. Fil: Kariuki, Samuel. Kenya Medical Research Institute. Centre for Microbiology Research; Kenia. Fil: Maclennan, Calman A. Wellcome Trust Sanger Institute; Reino Unido. Fil: Onsare, Robert S. Kenya Medical Research Institute. Centre for Microbiology Research; Kenia. Fil: Weill, François-Xavier. Institut Pasteur; Francia. Fil: Le Hello, Simon. Institut Pasteur; Francia. Fil: Smith. Anthony M. National Institute for Communicable Diseases. Centre for Enteric Diseases; Sudáfrica. Fil: McClelland, Michael. University of California. Department of Microbiology and Molecular Genetics; Estados Unidos. Fil: Desai, Prerak. University of California. Department of Microbiology and Molecular Genetics; Estados Unidos. Fil: Parry, Christopher M. University of California. Department of Microbiology and Molecular Genetics; Estados Unidos. Fil: Cheesbrough, John. University of Liverpool. Department of Epidemiology and Population Health; Reino Unido. Fil: French, Neil. University of Liverpool. Institute of Infection and Global Health; Reino Unido. Fil: Campos, Josefina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Fil: Chabalgoity, Jose A. Universidad de la República. Facultad de Medicina. Instituto de Higiene; Uruguay. Fil: Betancor, Laura. Universidad de la República. Facultad de Medicina. Instituto de Higiene; Uruguay. Fil: Hopkins, Katie L. Public Health England. Antimicrobial Resistance and Healthcare-Associated Infections Reference Unit; Reino Unido. Fil: Nair, Satheesh. Public Health England. Gastrointestinal Bacteria Reference Unit; Reino Unido. Fil: Humphrey, Tom J. Swansea University. Swansea Medical School; Reino Unido. Fil: Lunguya, Octavie. National Institute of Biomedical Research, República Democrática del Congo. Fil: Cogan, Tristan A. University of Bristol. School of Veterinary Sciences; Reino Unido. Fil: Tapia, Milagritos D. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos. Fil: Sow, Samba O. Centre pour le Développement des Vaccins, Malí. Fil: Tennant, Sharon M. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos. Fil: Bornstein, Kristin. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos. Fil: Levine, Myron M. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos. Fil: Lacharme-Lora, Lizeth. University of Liverpool. Institute of Infection and Global Health; Reino Unido. Fil: Everett, Dean B. University of Liverpool. Institute of Infection and Global Health; Reino Unido. Fil: Kingsley, Robert A. Wellcome Trust Sanger Institute; Reino Unido. Fil: Parkhill, Julian. Wellcome Trust Sanger Institute; Reino Unido. Fil: Heyderman, Robert S. University of Malawi. College of Medicine. Malawi Liverpool Wellcome Trust Clinical Research Programme; Malaui. Fil: Dougan, Gordon. Wellcome Trust Sanger Institute; Reino Unido. Fil: Gordon, Melita A. University of Malawi. College of Medicine. Malawi Liverpool Wellcome Trust Clinical Research Programme; Malaui. Fil: Thomson, Nicholas R. Wellcome Trust Sanger Institute; Reino Unido. |
URI: | http://sgc.anlis.gob.ar/handle/123456789/1695 | DOI: | 10.1038/ng.3644 | Rights: | Open Access |
Appears in Collections: | Publicaciones INEI |
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emss-69240.pdf | Artículo en inglés | 1.74 MB | Adobe PDF | View/Open |
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