Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/1649
Title: Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms
Authors: Segura, A 
de Castillo, M. C. 
Núñez, V 
Yarlequé, A 
Gonçalves, L R C 
Villalta, M 
Bonilla, C 
Herrera, M 
Vargas, M. 
Fernández, M 
Yano, M Y 
Araújo, H P 
Boller, M A A 
León, P 
Tintaya, B 
Sano-Martins, I S 
Gómez, A 
Fernández, G P 
Geoghegan, Patricia A. 
Higashi, H G 
León, G 
Gutiérrez, J M 
Keywords: Mordeduras de Serpientes;América Latina;Argentina;Brasil;Perú;Bolivia;Costa Rica;Antivenenos
Issue Date: Nov-2010
Journal: Toxicon : official journal of the International Society on Toxinology 
Abstract: 
Species of the genus Bothrops induce the vast majority of snakebite envenomings in Latin America. A preclinical study was performed in the context of a regional network of public laboratories involved in the production, quality control and development of antivenoms in Latin America. The ability of seven polyspecific antivenoms, produced in Argentina, Brazil, Peru, Bolivia, Colombia and Costa Rica, to neutralize lethal, hemorrhagic, coagulant, defibrinogenating and myotoxic activities of the venoms of Bothrops neuwiedi (diporus) (Argentina), Bothrops jararaca (Brazil), B. neuwiedi (mattogrossensis) (Bolivia), Bothrops atrox (Peru and Colombia) and Bothrops asper (Costa Rica) was assessed using standard laboratory tests. Despite differences in the venom mixtures used in the immunization of animals for the production of these antivenoms, a pattern of extensive cross-neutralization was observed between these antivenoms and all the venoms tested, with quantitative differences in the values of effective doses. This study reveals the capacity of these antivenoms to neutralize, in preclinical tests, homologous and heterologous Bothrops venoms in Central and South America, and also highlight quantitative differences in the values of Median Effective Doses (ED50s) between the various antivenoms.
Description: 
Fil: Segura, A. Universidad de Costa Rica. Instituto Clodomiro Picado; Costa Rica.

Fil: de Castillo, M. C. INVIMA, Bogotá; Colombia.

Fil: Núñez, V. Universidad de Antioquia, Medellín; Colombia.

Fil: Yarlequé, A. Universidad Nacional Mayor de San Marcos, Lima; Perú.

Fil: Gonçalves, L. R. C. Instituto Butantan, São Paulo; Brasil.

Fil: Villalta, M. Universidad de Costa Rica. Instituto Clodomiro Picado; Costa Rica.

Fil: Bonilla, C. Instituto Nacional de Salud, Lima; Perú.

Fil: Herrera, M. Universidad de Costa Rica. Instituto Clodomiro Picado; Costa Rica.

Fil: Vargas, M. Universidad de Costa Rica. Instituto Clodomiro Picado; Costa Rica.

Fil: Fernández, M. Universidad de Antioquia, Medellín; Colombia.

Fil: Yano, M. Y. Instituto Butantan, São Paulo; Brasil.

Fil: Araújo, H. P. INCQS, Fiocruz, Rio de Janeiro; Brasil.

Fil: Boller, M. A. A. INCQS, Fiocruz, Rio de Janeiro; Brasil.

Fil: León, P. INVIMA, Bogotá; Colombia.

Fil: Tintaya, B. Instituto Nacional de Salud, Lima; Perú.

Fil: Sano-Martins, I. S. Instituto Butantan, São Paulo; Brasil.

Fil: Gómez, A. Instituto Nacional de Salud, Bogotá; Colombia.

Fil: Fernández, G. P. INLASA, La Paz; Bolivia.

Fil: Geoghegan, Patricia A. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.

Fil: Higashi, H. G. Instituto Butantan, São Paulo; Brasil.

Fil: León, G. Universidad de Costa Rica. Instituto Clodomiro Picado; Costa Rica.

Fil: Gutiérrez, J. M. Universidad de Costa Rica. Instituto Clodomiro Picado; Costa Rica.
URI: http://sgc.anlis.gob.ar/handle/123456789/1649
ISSN: 0041-0101
DOI: https://doi.org/10.1016/j.toxicon.2010.07.001
Rights: Closed Access
Appears in Collections:Publicaciones CNCCB

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