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Título : Phylogeographic Analysis Reveals Multiple International transmission Events Have Driven the Global Emergence of Escherichia coli O157:H7
Autor : Franz, Eelco 
Rotariu, Ovidiu 
Lopes, Bruno S 
MacRae, Marion 
Bono, James L 
Laing, Chad 
Gannon, Victor 
Söderlund, Robert 
van Hoek, Angela H A M 
Friesema, Ingrid 
French, Nigel P 
George, Tessy 
Biggs, Patrick J 
Jaros, Patricia 
Rivas, Marta 
Chinen, Isabel 
Campos, Josefina 
Jernberg, Cecilia 
Gobius, Kari 
Mellor, Glen E 
Chandry, P Scott 
Perez-Reche, Francisco 
Forbes, Ken J 
Strachan, Norval J C 
Palabras clave : Escherichia coli O157;Infecciones por Escherichia coli;Filogeografía;Secuenciación Completa del Genoma
Fecha de publicación : 18-jul-2019
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 
Resumen : 
Background: Shiga toxin-producing Escherchia coli (STEC) O157:H7 is a zoonotic pathogen that causes numerous food and waterborne disease outbreaks. It is globally distributed, but its origin and the temporal sequence of its geographical spread are unknown.

Methods: We analyzed whole-genome sequencing data of 757 isolates from 4 continents, and performed a pan-genome analysis to identify the core genome and, from this, extracted single-nucleotide polymorphisms. A timed phylogeographic analysis was performed on a subset of the isolates to investigate its worldwide spread.

Results: The common ancestor of this set of isolates occurred around 1890 (1845-1925) and originated from the Netherlands. Phylogeographic analysis identified 34 major transmission events. The earliest were predominantly intercontinental, moving from Europe to Australia around 1937 (1909-1958), to the United States in 1941 (1921-1962), to Canada in 1960 (1943-1979), and from Australia to New Zealand in 1966 (1943-1982). This pre-dates the first reported human case of E. coli O157:H7, which was in 1975 from the United States.

Conclusions: Inter- and intra-continental transmission events have resulted in the current international distribution of E. coli O157:H7, and it is likely that these events were facilitated by animal movements (eg, Holstein Friesian cattle). These findings will inform policy on action that is crucial to reduce the further spread of E. coli O157:H7 and other (emerging) STEC strains globally.
Descripción : 
Fil: Franz, Eelco. National Institute for Public Health and the Environment. Centre for Infectious Disease Control; Países Bajos.

Fil: Rotariu, Ovidiu. The University of Aberdeen. School of Biological Sciences; Gran Bretaña.

Fil: Lopes, Bruno S. The University of Aberdeen. School of Medicine. Medical Sciences & Nutrition; Gran Bretaña.

Fil: MacRae, Marion. The University of Aberdeen. School of Medicine. Medical Sciences & Nutrition; Gran Bretaña.

Fil: Bono, James L. United States Department of Agriculture. Agricultural Research Service. US Meat Animal Research Center, Clay Center, Nebraska; Estados Unidos.

Fil: Laing, Chad. Public Health Agency of Canada. National Microbiology Laboratory. Lethbridge, Alberta; Canadá.

Fil: Gannon, Victor. Public Health Agency of Canada. National Microbiology Laboratory. Lethbridge, Alberta; Canadá.

Fil: Söderlund, Robert. National Veterinary Institute, Upsala; Suecia.

Fil: van Hoek, Angela H. A. M. National Institute for Public Health and the Environment. Centre for Infectious Disease Control; Países Bajos.

Fil: Friesema, Ingrid. National Institute for Public Health and the Environment. Centre for Infectious Disease Control; Países Bajos.

Fil: French, Nigel P. Massey University. School of Veterinary Science. Infectious Disease Research Centre. Molecular EpiLab, Palmerston North; Nueva Zelanda.

Fil: George, Tessy. Massey University. School of Veterinary Science. Infectious Disease Research Centre. Molecular EpiLab, Palmerston North; Nueva Zelanda.

Fil: Biggs, Patrick J. Massey University. School of Veterinary Science. Infectious Disease Research Centre. Molecular EpiLab, Palmerston North; Nueva Zelanda.

Fil: Jaros, Patricia. Massey University. School of Veterinary Science. Infectious Disease Research Centre. Molecular EpiLab, Palmerston North; Nueva Zelanda.

Fil: Rivas, Marta. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.

Fil: Chinen, Isabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.

Fil: Campos, Josefina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.

Fil: Jernberg, Cecilia. The Public Health Agency of Sweden. Department of Microbiology, Estocolmo; Suecia.

Fil: Gobius, Kari. The Commonwealth Scientific and Industrial Research Organisation Agriculture and Food, Werribee, Victoria; Australia.

Fil: Mellor, Glen E. The Commonwealth Scientific and Industrial Research Organisation Agriculture and Food, Werribee, Victoria; Australia.

Fil: Chandry, P Scott. The Commonwealth Scientific and Industrial Research Organisation Agriculture and Food, Werribee, Victoria; Australia.

Fil: Perez-Reche, Francisco. University of Aberdeen. SUPA, School of Natural and Computing Sciences. Institute of Complex Systems and Mathematical Biology; Gran Bretaña.

Fil: Forbes, Ken J. The University of Aberdeen. School of Medicine. Medical Sciences & Nutrition; Gran Bretaña.

Fil: Strachan, Norval J. C. The University of Aberdeen. School of Biological Sciences; Gran Bretaña.
URI : https://pubmed.ncbi.nlm.nih.gov/30371758/
http://sgc.anlis.gob.ar/handle/123456789/1569
ISSN : 1537-6591
DOI: 10.1093/cid/ciy919
Derechos: Closed Access
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