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Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/1507
DC FieldValueLanguage
dc.contributor.authorBua, Jacquelinees
dc.contributor.authorÅslund, Lenaes
dc.contributor.authorPereyra, Nes
dc.contributor.authorGarcía, Gabriela Andreaes
dc.contributor.authorBontempi, Estebanes
dc.contributor.authorRuiz, Andrés Marianoes
dc.date.accessioned2019-12-13T18:33:21Z-
dc.date.available2019-12-13T18:33:21Z-
dc.date.issued2001-06-12-
dc.identifier.issn0378-1097-
dc.identifier.urihttp://sgc.anlis.gob.ar/handle/123456789/1507-
dc.identifier.urihttps://academic.oup.com/femsle/article/200/1/43/550163-
dc.descriptionFil: Bua, Jacqueline. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.es
dc.descriptionFil: Aslund, Lena. Rudbeck Laboratory. Department of Genetics and Pathology; Suecia.es
dc.descriptionFil: Pereyra, Natalia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.es
dc.descriptionFil: Ruiz, Andrés Mariano. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.es
dc.descriptionFil: Bontempi, Esteban J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología Dr. Mario Fatala Chaben; Argentina.es
dc.description.abstractThe immunosuppressive drug cyclosporin A (CsA) has shown antiparasitic activity against several protozoans and helminths, when complexed to proteins called cyclophilins (CyPs). In this paper, the molecular characterisation of one member of the CyP family in Trypanosoma cruzi is reported. TcCyP19 gene proved to be highly conserved compared to CyPs from other organisms and was highly homologous to a Trypanosoma brucei brucei CyPA. This gene was expressed in Escherichia coli and the purified recombinant protein exhibited a peptidyl prolyl cis-trans isomerase activity that was inhibited by CsA (IC(50) = 18.4 + /-0.8 nM). The TcCyP19 gene was located on two chromosomal bands in T. cruzi CL Brener clone.es
dc.language.isoenes
dc.relation.ispartofFEMS microbiology letterses
dc.subjectEnfermedad de Chagases
dc.subjectCiclosporinaes
dc.subjectEscherichia colies
dc.titleCharacterisation of a cyclophilin isoform in Trypanosoma cruzies
dc.typeArtículoes
dc.identifier.doi10.1111/j.1574-6968.2001.tb10690.x-
anlis.essnrd1-
item.openairetypeArtículo-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
crisitem.author.deptInstituto Nacional de Parasitología (INP)-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
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