Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/1485
DC Field | Value | Language |
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dc.contributor.author | Albareda, María Cecilia | en_US |
dc.contributor.author | Olivera, Gabriela Carina | en_US |
dc.contributor.author | Laucella, Susana A. | en_US |
dc.contributor.author | Alvarez, María Gabriela | en_US |
dc.contributor.author | Fernandez, Esteban Rodrigo | en_US |
dc.contributor.author | Lococo, Bruno | en_US |
dc.contributor.author | Viotti, Rodolfo | en_US |
dc.contributor.author | Tarleton, Rick L | en_US |
dc.contributor.author | Postan, Miriam | en_US |
dc.date.accessioned | 2019-12-09T20:36:22Z | - |
dc.date.available | 2019-12-09T20:36:22Z | - |
dc.date.issued | 2009-09-15 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/1485 | - |
dc.description.abstract | Previously we found that the frequency of IFN-gamma-producing CD8(+) T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas disease along with low levels of IL-2-secreting CD8(+) T cells in all clinical stages. This impairment of the parasite-specific T cell responses was associated with phenotypic features of immune senescence of the CD8(+) T cell compartment. These data prompted us to address the question of whether the CD4(+) T cell compartment also experiences signs of exhaustion. Thus, we performed a functional and phenotypical characterization of T. cruzi-specific and overall CD4(+) T cells in chronically infected subjects with different degrees of cardiac dysfunction. The results show an inverse association between disease severity and the frequency of T. cruzi-specific IFN-gamma-producing CD4(+) T cells. The high expression of CD27 and CD28 with a relative low expression of CD57 found on CD4(+)IFN-gamma(+) T cells suggests that the effector T cell pool in chronic T. cruzi infection includes a high proportion of newly recruited T cells, but a low frequency of long-term memory cells. The total CD4(+) T cell compartment shows signs of senescence and later stages of differentiation associated with more severe stages of the disease. These findings support the hypothesis that long-term T. cruzi infection in humans might exhaust long-lived memory T cells. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of immunology (Baltimore, Md. : 1950) | en_US |
dc.title | Chronic human infection with Trypanosoma cruzi drives CD4+ T cells to immune senescence | en_US |
dc.type | Artículo | en_US |
dc.identifier.doi | 10.4049/jimmunol.0900852 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | Artículo | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Instituto Nacional de Parasitología (INP) | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
Appears in Collections: | Publicaciones INP |
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File | Description | Size | Format | |
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nihms184858.pdf | Artículo en inglés | 791.05 kB | Adobe PDF | View/Open |
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