Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/1435
DC FieldValueLanguage
dc.contributor.authorVolta, Bibiana J.es
dc.contributor.authorBustos, Patricia L.es
dc.contributor.authorCardoni, Rita L.es
dc.contributor.authorDe Rissio, Ana Maríaes
dc.contributor.authorLaucella, Susana A.es
dc.contributor.authorBua, Jacquelinees
dc.date.accessioned2019-12-04T19:31:43Z-
dc.date.available2019-12-04T19:31:43Z-
dc.date.issued2016-06-01-
dc.identifier.issn1550-6606-
dc.identifier.urihttp://sgc.anlis.gob.ar/handle/123456789/1435-
dc.descriptionFil: Volta, Bibiana J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.es
dc.descriptionFil: Bustos, Patricia L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.es
dc.descriptionFil: Cardoni, Rita L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.es
dc.descriptionFil: De Rissio, Ana María. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.es
dc.descriptionFil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.es
dc.descriptionFil: Bua, Jacqueline. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.es
dc.description.abstractTrypanosoma cruzi, the causing agent of Chagas disease, leads to an activation of the immune system in congenitally infected infants. In this study, we measured a set of cytokines/chemokines and the levels of parasitemia by quantitative PCR in the circulation of neonates born to T. cruzi-infected mothers to evaluate the predictive value of these mediators as biomarkers of congenital transmission. We conducted a retrospective cohort study of 35 infants with congenital T. cruzi infection, of which 15 and 10 infants had been diagnosed by detection of parasites by microscopy in the first and sixth month after delivery, respectively, and the remaining 10 had been diagnosed by the presence of T. cruzi-specific Abs at 10-12 mo old. Uninfected infants born to either T. cruzi-infected or uninfected mothers were also evaluated as controls. The plasma levels of IL-17A, MCP-1, and monokine induced by IFN-γ were increased in infants congenitally infected with T. cruzi, even before they developed detectable parasitemia or seroconversion. Infants diagnosed between 6 and 12 mo old also showed increased levels of IL-6 and IL-17F at 1 mo of age. Conversely, infants who did not develop congenital T. cruzi infection had higher levels of IFN-γ than infected infants born to uninfected mothers. Monokine induced by IFN-γ, MCP-1, and IFN-γ production induced in T. cruzi-infected infants correlated with parasitemia, whereas the plasma levels of IL-17A, IL-17F, and IL-6 were less parasite load dependent. These findings support the existence of a distinct profile of cytokines and chemokines in the circulation of infants born to T. cruzi-infected mothers, which might predict congenital infection.es
dc.formatpdf-
dc.language.isoenes
dc.publisherAmerican Association of Immunologistses
dc.relation.ispartofJournal of immunology (Baltimore, Md. : 1950)es
dc.rightsOpen Access-
dc.sourceJournal of immunology 2016; 196(11):4596-602.-
dc.subjectTrypanosoma Cruzies
dc.subjectEnfermedad de Chagases
dc.titleSerum Cytokines as Biomarkers of Early Trypanosoma cruzi infection by Congenital Exposurees
dc.typeArtículoes
dc.identifier.doi10.4049/jimmunol.1502504-
anlis.essnrd1-
item.openairetypeArtículo-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
crisitem.author.deptInstituto Nacional de Parasitología (INP)-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
Appears in Collections:Publicaciones INP
Files in This Item:
File Description SizeFormat
4596.full.pdfArtículo en inglés1.17 MBAdobe PDFThumbnail
View/Open
Show simple item record

Page view(s)

29
checked on Mar 29, 2024

Download(s)

25
checked on Mar 29, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.