Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/1414
DC Field | Value | Language |
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dc.contributor.author | Albareda, María Cecilia | en_US |
dc.contributor.author | Natale, María A | en_US |
dc.contributor.author | De Rissio, Ana María | en_US |
dc.contributor.author | Fernandez, Marisa | en_US |
dc.contributor.author | Serjan, Alicia | en_US |
dc.contributor.author | Alvarez, María G | en_US |
dc.contributor.author | Cooley, Gretchen | en_US |
dc.contributor.author | Shen, Huifeng | en_US |
dc.contributor.author | Viotti, Rodolfo | en_US |
dc.contributor.author | Bua, Jacqueline | en_US |
dc.contributor.author | Castro Eiro, Melisa D | en_US |
dc.contributor.author | Nuñez, Myriam | en_US |
dc.contributor.author | Fichera, Laura E. | en_US |
dc.contributor.author | Lococo, Bruno | en_US |
dc.contributor.author | Scollo, Karenina | en_US |
dc.contributor.author | Tarleton, Rick L | en_US |
dc.contributor.author | Laucella, Susana A. | en_US |
dc.date.accessioned | 2019-11-29T19:55:25Z | - |
dc.date.available | 2019-11-29T19:55:25Z | - |
dc.date.issued | 2018 | - |
dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/1414 | - |
dc.description.abstract | Background: In contrast to adults, Trypanosoma cruzi-infected children have more broadly functional Trypanosoma cruzi-specific T cells, and the total T-cell compartment exhibits fewer signs of immune exhaustion. However, not much is known about the link between immunocompetence and the treatment efficacy for human Chagas disease. Methods: Using cytokine enzyme-linked immunosorbent spot (ELISPOT) polychromatic flow cytometry, cytometric bead assay, multiplex serological assays and quantitative PCR, we evaluated T. cruzi-specific T-cell and antibody immune responses, T-cell phenotypes and parasitemia in children in the early chronic phase of Chagas disease undergoing anti-Trypanosoma cruzi treatment. Results: Treatment with benznidazole or nifurtimox induced a decline in T. cruzi-specific IFN-γ- and IL-2-producing cells and proinflammatory cytokines and chemokines. T-cell responses became detectable after therapy in children bearing T-cell responses under background levels prior to treatment. The total frequencies of effector, activated and antigen-experienced T cells also decreased following anti-T. cruzi therapy, along with an increase in T cells expressing the receptor of the homeostatic cytokine IL-7. Posttreatment changes in several of these markers distinguished children with a declining serologic response suggestive of successful treatment from those with sustained serological responses in a 5-year follow-up study. A multivariate analysis demonstrated that lower frequency of CD4+CD45RA-CCR7-CD62L- T cells prior to drug therapy was an independent indicator of successful treatment. Conclusions: These findings further validate the usefulness of alternative metrics to monitor treatment outcomes. Distinct qualitative and quantitative characteristics of T cells prior to drug therapy may be linked to treatment efficacy. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Frontiers in immunology | en_US |
dc.subject | Linfocitos T | en_US |
dc.subject | Trypanosoma cruzi | en_US |
dc.subject | benznidazole | en_US |
dc.subject | Nifurtimox | en_US |
dc.subject | infección pediátrica | en_US |
dc.title | Distinct Treatment Outcomes of Antiparasitic Therapy in Trypanosoma cruzi-Infected Children Is Associated With Early Changes in Cytokines, Chemokines, and T-Cell Phenotypes | en_US |
dc.type | Artículo | en_US |
dc.identifier.doi | 10.3389/fimmu.2018.01958 | - |
item.openairetype | Artículo | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
crisitem.author.dept | Instituto Nacional de Parasitología (INP) | - |
crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
Appears in Collections: | Publicaciones INP |
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File | Description | Size | Format | |
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fimmu-09-01958.pdf | Artículo en inglés | 3.82 MB | Adobe PDF | View/Open |
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