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|Title:||Bactericidal and hemolytic activities of synthetic peptides derived from granulysin||Authors:||Siano, A
Imaz, María Susana
Perín, J C
Santi, M N
Zerbini, Elsa V.
|Issue Date:||Apr-2010||Journal:||Protein and peptide letters||Abstract:||
Granulysin is a human polypeptide produced by cytolytic cells active against a broad range of microbes. Three peptides covering the regions 25-50 (Gr-1 and Gr-2) and 39-62 (Gr-3) of granulysin were synthesized, and their in vitro activity against Mycobacterium tuberculosis was evaluated. The most active peptide was Gr-1C, containing a disulphide bridge, with Minimal Inhibitory Concentration value of 10.1 microM. In concentrations of up to 50 microM, Gr-1 and Gr2 didn't exceed 30% of hemolysis.
|Appears in Collections:||Publicaciones INER|
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