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Title: HIV infection and geographically bound transmission of drug-resistant tuberculosis, Argentina
Authors: Ritacco, Viviana 
López, Beatriz 
Ambroggi, Marta 
Palmero, Domingo 
Salvadores, Bernardo 
Gravina, Elida 
Mazzeo, Eduardo 
Imaz, Susana 
Barrera, Lucía 
Issue Date: Nov-2012
Journal: Emerging infectious diseases 
During 2003-2009, the National Tuberculosis (TB) Laboratory Network in Argentina gave 830 patients a new diagnosis of multidrug-resistant (MDR) TB and 53 a diagnosis of extensively drug- resistant (XDR) TB. HIV co-infection was involved in nearly one third of these cases. Strain genotyping showed that 7 major clusters gathered 56% of patients within restricted geographic areas. The 3 largest clusters corresponded to epidemic MDR TB strains that have been undergoing transmission for >10 years. The indigenous M strain accounted for 29% and 40% of MDR and XDR TB cases, respectively. Drug-resistant TB trends in Argentina are driven by spread of a few strains in hotspots where the rate of HIV infection is high. To curb transmission, the national TB program is focusing stringent interventions in these areas by strengthening infection control in large hospitals and prisons, expediting drug resistance detection, and streamlining information-sharing systems between HIV and TB programs.
DOI: 10.3201/eid1811.120126
Appears in Collections:Publicaciones INEI

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