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Title: An Stx-EAEC O59:NM[H19] strain isolated from a hemolytic uremic syndrome case in Argentina
Authors: Carbonari, Claudia C 
Ricciardi, Miriam 
Calvo, Ana Rodríguez 
Montes, Alejandro 
Deza, Natalia L 
Conde Valentino, María A 
Zolezzi, Gisela 
Baschkier, Ariela 
Vago, Mariano 
Acosta, Denise 
Manfredi, Eduardo A 
Miliwebsky, Elizabeth 
Chinen, Isabel 
Rivas, Marta 
Keywords: EAEC-Stx;Sistema de vigilancia;HUS;O59:NM[H19];SUH;Stx-EAEC
Issue Date: 29-Jun-2019
Journal: Revista Argentina de microbiologia 
Abstract: Shiga toxin-producing Escherichia coli (STEC) are a heterogeneous group of foodborne pathogens causing a broad spectrum of human disease, from uncomplicated diarrhea to hemolytic uremic syndrome (HUS). In this study, we report an HUS case associated with an O59:NM[H19] strain, harboring stx2a, iha, lpfAO26, lpfAO113 genes associated with STEC, and aatA, aap, pic, sigA, agg4A genes associated with enteroaggregative E. coli (EAEC), named Stx-EAEC. The strain showed low toxicity on Vero cells, and was resistant to streptomycin and trimethoprim/sulfonamides. The child carried the bacteria for more than 100 days. Since the large outbreak associated with Stx-EAEC O104:H4, many strains with similar profiles have been described. In Germany, an O59:NM[H19] strain, with comparable characteristics to the Argentine strain, was isolated from a bloody diarrhea case. In Argentina, this is the first report of an HUS case associated with a Stx-EAEC infection, and represents a new challenge for the surveillance system.
ISSN: 0325-7541
DOI: 10.1016/j.ram.2019.03.006
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