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Title: Exploring the "Latin American Mediterranean" family and the RDRio lineage in Mycobacterium tuberculosis isolates from Paraguay, Argentina and Venezuela
Authors: Díaz Acosta, Chyntia Carolina 
Russomando, Graciela 
Candia, Norma 
Ritacco, Viviana 
Vasconcellos, Sidra E G 
de Berrêdo Pinho Moreira, Marcia 
de Romero, Nilda J. 
Morcillo, Nora 
De Waard, Jacobus Henri 
Gomes, Harrison Magdinier 
Suffys, Philip Noel 
Keywords: Mycobacterium tuberculosis;Técnicas de Genotipaje;LAM;Paraguay
Issue Date: 13-Jun-2019
Journal: BMC microbiology 
Abstract: The Latin American & Mediterranean (LAM) spoligotype family is one of the most successful genotype of Mycobacterium tuberculosis worldwide and particularly prevalent in South-America. Within this family, a sublineage named Region of Difference Rio (RDRio) was reported initially in Brazil and is characterized by a genomic deletion of about 26.3 kb. This lineage seems to show a specific adaptation to the Euro-Latin American population. In this context, we sought to evaluate the LAM family and the presence of the RDRio genotype in samples from three Latin American countries including Paraguay, Venezuela and Argentina. To detect LAM strains reliably we applied a typing scheme using spoligotyping, 12 loci MIRU-VNTR, the Ag85C103 SNP and the regions of difference RDRio and RD174. IS6110-RFLP results were also used when available.
DOI: 10.1186/s12866-019-1479-6
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