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Title: Resistance to β-lactams in enterococci
Authors: Gagetti, Paula 
Bonofiglio, Laura 
García Gabarrot, Gabriela 
Kaufman, Sara 
Mollerach, Marta 
Vigliarolo, Laura 
von Specht, Martha H. 
Toresani, Inés 
Lopardo, Horacio A 
Keywords: Resistencia antimicrobiana;Enterococcus faecalis;Enterococcus faecium;Enterococos;β-Lactámicos
Issue Date: 2019
Journal: Revista Argentina de microbiologia 
Enterococci are intrinsically resistant to several antimicrobial classes and show a great ability to acquire new mechanisms of resistance. Resistance to β-lactam antibiotics is a major concern because these drugs either alone or in combination are commonly used for the treatment of enterococcal infections. Ampicillin resistance, which is rare in Enterococcus faecalis, occurs in most of the hospital-associated Enterococcus faecium isolates. High-level resistance to ampicillin in E. faecium is mainly due to the enhanced production of PBP5 and/or by polymorphisms in the beta subunit of this protein. The dissemination of high-level ampicillin resistance can be the result of both clonal spread of strains with mutated pbp5 genes and horizontal gene transfer.
ISSN: 0325-7541
DOI: 10.1016/j.ram.2018.01.007
Appears in Collections:Publicaciones INEI

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