Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/1319
Title: Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection
Authors: Venkatesan, Sudhir 
Myles, Puja R 
Bolton, Kirsty J 
Muthuri, Stella G 
Al Khuwaitir, Tarig 
Anovadiya, Ashish P 
Azziz-Baumgartner, Eduardo 
Bajjou, Tahar 
Bassetti, Matteo 
Beovic, Bojana 
Bertisch, Barbara 
Bonmarin, Isabelle 
Booy, Robert 
Borja-Aburto, Victor H 
Burgmann, Heinz 
Cao, Bin 
Carratala, Jordi 
Chinbayar, Tserendorj 
Cilloniz, Catia 
Denholm, Justin T 
Dominguez, Samuel R 
Duarte, Pericles A D 
Dubnov-Raz, Gal 
Fanella, Sergio 
Gao, Zhancheng 
Gérardin, Patrick 
Giannella, Maddalena 
Gubbels, Sophie 
Herberg, Jethro 
Higuera Iglesias, Anjarath Lorena 
Hoeger, Peter H 
Hu, Xiao Yun 
Islam, Quazi T 
Jiménez, Mirela F 
Keijzers, Gerben 
Khalili, Hossein 
Kusznierz, Gabriela F. 
Kuzman, Ilija 
Langenegger, Eduard 
Lankarani, Kamran B 
Leo, Yee-Sin 
Libster, Romina 
Linko, Rita 
Madanat, Faris 
Maltezos, Efstratios 
Mamun, Abdullah 
Manabe, Toshie 
Metan, Gokhan 
Mickiene, Auksė 
Mikić, Dragan 
Mohn, Kristin G I 
Oliva, Maria E 
Ozkan, Mehpare 
Parekh, Dhruv 
Paul, Mical 
Rath, Barbara A 
Refaey, Samir 
Rodríguez, Alejandro H 
Sertogullarindan, Bunyamin 
Skręt-Magierło, Joanna 
Somer, Ayper 
Talarek, Ewa 
Tang, Julian W 
To, Kelvin 
Tran, Dat 
Uyeki, Timothy M 
Vaudry, Wendy 
Vidmar, Tjasa 
Zarogoulidis, Paul 
Nguyen-Van-Tam, Jonathan S 
PRIDE Consortium Investigators 
Keywords: Neuraminidasa;Antivirales;Gripe Humana
Issue Date: 17-Jul-2019
Journal: The Journal of infectious diseases 
Abstract: 
Background. The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear.
Methods. We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects
negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid treatment, we calculated incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Patients with a LoS of <1 day and those who died while hospitalized were excluded.
Results. We analyzed data on 18 309 patients from 70 clinical centers. After adjustment, NAI treatment initiated at hospitalization was associated with a 19% reduction in the LoS among patients with clinically suspected or laboratory-confirmed influenza A(H1N1)pdm09 infection (IRR, 0.81; 95% CI,.78–.85), compared with later or no initiation of NAI treatment. Similar statistically significant associations were seen in all clinical subgroups. NAI treatment (at any time), compared with no NAI treatment, and NAI treatment initiated <2 days after symptom onset, compared with later or no initiation of NAI treatment, showed mixed patterns of association with the LoS.
Conclusions. When patients hospitalized with influenza are treated with NAIs, treatment initiated on admission, regardless of time since symptom onset, is associated with a reduced LoS, compared with later or no initiation of treatment.
Description: 
Fil: Venkatesan, Sudhir. Division of Epidemiology and Public Health, Nottingham; Inglaterra.

Fil: Myles, Puja R. Division of Epidemiology and Public Health, Nottingham; Inglaterra.

Fil: Bolton, Kirsty J. University of Nottingham. School of Mathematical Sciences, Nottingham; Inglaterra.

Fil: Muthuri, Stella G. University College London. MRC Unit for Lifelong Health and Ageing; Inglaterra.

Fil: Al Khuwaitir, Tarig. King Saud Medical City. Department of Medicine, Riad; Arabia Saudí.

Fil: Anovadiya, Ashish P. Government Medical College and Sir Takhtasinhji General Hospital. Department of Pharmacology, Bhavnagar; India.

Fil: Azziz-Baumgartner, Eduardo. Centers for Disease Control and Prevention. National Center for Immunization and Respiratory Diseases. Influenza Division, Atlanta, Georgia; Estados Unidos.

Fil: Bajjou, Tahar. Centers for Disease Control and Prevention. National Center for Immunization and Respiratory Diseases. Influenza Division, Atlanta, Georgia; Estados Unidos.

Fil: Bassetti, Matteo. University Mohammed V-Souissi. Faculty of Medicine and Pharmacy. Mohammed V Military Teaching Hospital. Biosafety Level 3 and Research Laboratory, Rabat; Marruecos.

Fil: Beovic, Bojana. Santa Maria Misericordia Hospital, Údine; Italia.

Fil: Bertisch, Barbara. University Medical Center. Department of Infectious Diseases, Liubliana; Eslovenia.

Fil: Bonmarin, Isabelle. University of Geneva. Institute of Global Health; Suiza.

Fil: Booy, Robert. Institut de Veille Sanitaire, Saint-Maurice; Francia.

Fil: Borja-Aburto, Victor H. University of Sydney. Children’s Hospital at Westmead. National Centre for Immunisation Research and Surveillance; Australia.

Fil: Burgmann, Heinz. Instituto Mexicano del Seguro Social; México.

Fil: Cao, Bin. Medical University of Vienna; Austria.

Fil: Carratala, Jordi. Capital Medical University. Beijing Chao-Yang Hospital, Pekín; China.

Fil: Chinbayar, Tserendorj. Bellvitge University Hospital. Bellvitge Biomedical Research Institute. Department of Infectious Diseases. Spanish Network for Research in Infectious Diseases, Bellvitge; España.

Fil: Cilloniz, Catia. CIBERES. University of Barcelona. August Pi I Sunyer Biomedical Research Institute. Hospital Clinic, Barcelona; España.

Fil: Denholm, Justin T. Peter Doherty Institute for Infection and Immunity. Victorian Infectious Diseases Service and Department of Microbiology and Immunology, Parkville, Maryland; Estados Unidos.

Fil: Dominguez, Samuel R. University of Colorado School of Medicine. Children’s Hospital Colorado. Department of Pediatric Infectious Diseases, Aurora; Estados Unidos.

Fil: Duarte, Pericles A. D. Universidade Estadual do Oeste do Paraná–UNIOESTE, Cascavel; Brasil.

Fil: Dubnov-Raz, Gal. Sheba Medical Center. Edmond and Lily Safra Children’s Hospital, Ramat Gan; Israel.

Fil: Fanella, Sergio. University of Manitoba. Section of Pediatric Infectious Diseases, Winnipeg; Canadá.

Fil: Gao, Zhancheng. Peking University People’s Hospital. Department of Respiratory and Critical Care Medicine, Pekín; China.

Fil: Gérardin, Patrick. Pôle Femme Mère Enfant; Francia.

Fil: Giannella, Maddalena. University of Bologna. Sant’Orsola Malpighi Hospital. Department of Clinical and Surgical Sciences, Bolonia; Italia.

Fil: Gubbels, Sophie. Statens Serum Institut. Sector for National Health Documentation and Research. Department of Infectious Disease Epidemiology, Copenhagen; Dinamarca.

Fil: Herberg, Jethro. Imperial College. Division of Infectious Disease. Section of Paediatrics, Londres; Inglaterra.

Fil: Higuera Iglesias, Anjarath Lorena. Instituto Nacional de Enfermedades Respiratorias Dr. Ismael Cosío Villegas. Department of Research in Clinical Epidemiology, Ciudad de México; México.

Fil: Hoeger, Peter H. Catholic Children’s Hospital Wilhelmstift, Hamburgo; Alemania.

Fil: Hu, Xiao Yun. Peking Union Medical College Hospital, Pekín; China.

Fil: Islam, Quazi T. Dhaka Medical College Hospital, Bangladés; Asia del Sur.

Fil: Jiménez, Mirela F. Preceptora da Residência Médica do Hospital Fêmina. Departamento de Ginecologia e Obstetrícia–UFCSPA, Fêmina; Brasil.

Fil: Keijzers, Gerben. Gold Coast University Hospital, Gold Coast; Australia.

Fil: Khalili, Hossein. Tehran University of Medical Sciences. Faculty of Pharmacy. Department of Clinical Pharmacy, Teherán; Irán.

Fil: Kusznierz, Gabriela F. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Respiratorias; Argentina.

Fil: Kuzman, Ilija. University of Zagreb School of Medicine. University Hospital for Infectious Diseases; Croacia.

Fil: Langenegger, Eduard. Stellenbosch University–Tygerberg. Department of Obstetrics and Gynaecology,, Ciudad del Cabo; Sudáfrica.

Fil: Lankarani, Kamran B. Shiraz University of Medical Sciences. Health Policy Research Center, Shiraz; Irán.

Fil: Leo, Yee-Sin. Tan Tock Seng Hospital. Department of Infectious Diseases; Singapur.

Fil: Libster, Romina. Vanderbilt University. Department of Pediatrics, Nashville, Tennessee; Estados Unidos.

Fil: Linko, Rita. Helsinki University Hospital; Finlandia.

Fil: Madanat, Faris. King Hussein Cancer Center. Department of Pediatrics, Amán: Jordania.

Fil: Maltezos, Efstratios. Democritus University Thrace. University General Hospital of Alexandroupolis. Unit of Infectious Diseases; Grecia.

Fil: Mamun, Abdullah. British Columbia Centre for Disease Control, Vancouver; Canadá.

Fil: Manabe, Toshie. Teikyo University School of Medicine. Department of Hygiene and Public Health, Tokyo; Japón.

Fil: Metan, Gokhan. Hacettepe University. Faculty of Medicine. Department of Infectious Diseases and Clinical Microbiology, Angora; Turquía.

Fil: Mickiene, Auksė. Lithuanian University of Health Sciences, Kaunas; Lituania.

Fil: Mikić, Dragan. University of Bergen. Department of Clinical Science. Influenza Center; Noruega.

Fil: Mohn, Kristin G. I. University of Bergen. Department of Clinical Science. Influenza Center; Noruega.

Fil: Oliva, Maria E. Hospital San Martín de Paraná. Departamento de Control de Infecciones, Entre Ríos; Argentina.

Fil: Ozkan, Mehpare. Bahçeşehir University. Pediatric Neurology Department; Turquía.

Fil: Parekh, Dhruv. University of Birmingham. Institute of Inflammation and Ageing. Respiratory and Critical Care Medicine, Birmingham; Inglaterra.

Fil: Paul, Mical. Rambam Health Care Campus. Division of Infectious Diseases, Haifa; Israel.

Fil: Rath, Barbara A. Charité–University Medical Center Berlin. Department of Pediatrics, Berlín; Alemania.

Fil: Refaey, Samir. Ministry of Health and Population. Epidemiology and Surveillance Department, El Cairo; Egipto.

Fil: Rodríguez, Alejandro H. IISPV-URV-CIBERES. Hospital Joan XXIII. Critical Care Department, Tarragona; España.

Fil: Sertogullarindan, Bunyamin. Yuzuncu Yil University. Medical Faculty, Department of Pulmonary Medicine, Van; Turquía.

Fil: Skręt-Magierło, Joanna. Uniwersytet Rzeszowski, Rzeszow; Polonia.

Fil: Somer, Ayper. Istanbul University. Istanbul Medical Faculty. Department of Pediatric Infectious Diseases, Estambul; Turquía.

Fil: Talarek, Ewa. Medical University of Warsaw,. Department of Children`s Infectious Diseases, Varsovia; Polonia.

Fil: Tang, Julian W. University of Leicester. Department of Respiratory Sciences; Inglaterra.

Fil: To, Kelvin. University of Hong Kong. Queen Mary Hospital. Department of Microbiology. Carol Yu Centre for Infection and Division of Infectious Diseases, Hong Kong Special Administrative Region; China.

Fil: Tran, Dat. Oregon Health Authority. Public Health Division. Acute and Communicable Disease Prevention, Portland; Estados Unidos.

Fil: Uyeki, Timothy M. Centers for Disease Control and Prevention. National Center for Immunization and Respiratory Diseases. Influenza Division, Atlanta, Georgia; Estados Unidos.

Fil: Vaudry, Wendy. University of Alberta. Stollery Children’s Hospital. Department of Pediatrics. Division of Infectious Diseases, Edmonton; Canadá.

Fil: Vidmar, Tjasa. General Hospital Slovenj Gradec, Slovenj Gradec; Eslovenia.

Fil: Zarogoulidis, Paul. Aristotle University of Thessaloniki. “G. Papanikalaou” General Hospital. Pulmonary Department, Salónica; Grecia.

Fil: Nguyen-Van-Tam, Jonathan S. Division of Epidemiology and Public Health, Nottingham; Inglaterra.

Fil: PRIDE Consortium Investigators. University of Nottingham; Inglaterra.
URI: http://sgc.anlis.gob.ar/handle/123456789/1319
DOI: 10.1093/infdis/jiz152
1537-6613
Rights: Open Access
Creative Commons Attribution 4.0 International License
Appears in Collections:Publicaciones INER

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