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Title: | Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection | Authors: | Venkatesan, Sudhir Myles, Puja R Bolton, Kirsty J Muthuri, Stella G Al Khuwaitir, Tarig Anovadiya, Ashish P Azziz-Baumgartner, Eduardo Bajjou, Tahar Bassetti, Matteo Beovic, Bojana Bertisch, Barbara Bonmarin, Isabelle Booy, Robert Borja-Aburto, Victor H Burgmann, Heinz Cao, Bin Carratala, Jordi Chinbayar, Tserendorj Cilloniz, Catia Denholm, Justin T Dominguez, Samuel R Duarte, Pericles A D Dubnov-Raz, Gal Fanella, Sergio Gao, Zhancheng Gérardin, Patrick Giannella, Maddalena Gubbels, Sophie Herberg, Jethro Higuera Iglesias, Anjarath Lorena Hoeger, Peter H Hu, Xiao Yun Islam, Quazi T Jiménez, Mirela F Keijzers, Gerben Khalili, Hossein Kusznierz, Gabriela F. Kuzman, Ilija Langenegger, Eduard Lankarani, Kamran B Leo, Yee-Sin Libster, Romina Linko, Rita Madanat, Faris Maltezos, Efstratios Mamun, Abdullah Manabe, Toshie Metan, Gokhan Mickiene, Auksė Mikić, Dragan Mohn, Kristin G I Oliva, Maria E Ozkan, Mehpare Parekh, Dhruv Paul, Mical Rath, Barbara A Refaey, Samir Rodríguez, Alejandro H Sertogullarindan, Bunyamin Skręt-Magierło, Joanna Somer, Ayper Talarek, Ewa Tang, Julian W To, Kelvin Tran, Dat Uyeki, Timothy M Vaudry, Wendy Vidmar, Tjasa Zarogoulidis, Paul Nguyen-Van-Tam, Jonathan S PRIDE Consortium Investigators |
Keywords: | Neuraminidasa;Antivirales;Gripe Humana | Issue Date: | 17-Jul-2019 | Journal: | The Journal of infectious diseases | Abstract: | Background. The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear. Methods. We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid treatment, we calculated incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Patients with a LoS of <1 day and those who died while hospitalized were excluded. Results. We analyzed data on 18 309 patients from 70 clinical centers. After adjustment, NAI treatment initiated at hospitalization was associated with a 19% reduction in the LoS among patients with clinically suspected or laboratory-confirmed influenza A(H1N1)pdm09 infection (IRR, 0.81; 95% CI,.78–.85), compared with later or no initiation of NAI treatment. Similar statistically significant associations were seen in all clinical subgroups. NAI treatment (at any time), compared with no NAI treatment, and NAI treatment initiated <2 days after symptom onset, compared with later or no initiation of NAI treatment, showed mixed patterns of association with the LoS. Conclusions. When patients hospitalized with influenza are treated with NAIs, treatment initiated on admission, regardless of time since symptom onset, is associated with a reduced LoS, compared with later or no initiation of treatment. |
Description: | Fil: Venkatesan, Sudhir. Division of Epidemiology and Public Health, Nottingham; Inglaterra. Fil: Myles, Puja R. Division of Epidemiology and Public Health, Nottingham; Inglaterra. Fil: Bolton, Kirsty J. University of Nottingham. School of Mathematical Sciences, Nottingham; Inglaterra. Fil: Muthuri, Stella G. University College London. MRC Unit for Lifelong Health and Ageing; Inglaterra. Fil: Al Khuwaitir, Tarig. King Saud Medical City. Department of Medicine, Riad; Arabia Saudí. Fil: Anovadiya, Ashish P. Government Medical College and Sir Takhtasinhji General Hospital. Department of Pharmacology, Bhavnagar; India. Fil: Azziz-Baumgartner, Eduardo. Centers for Disease Control and Prevention. National Center for Immunization and Respiratory Diseases. Influenza Division, Atlanta, Georgia; Estados Unidos. Fil: Bajjou, Tahar. Centers for Disease Control and Prevention. National Center for Immunization and Respiratory Diseases. 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URI: | http://sgc.anlis.gob.ar/handle/123456789/1319 | DOI: | 10.1093/infdis/jiz152 1537-6613 |
Rights: | Open Access Creative Commons Attribution 4.0 International License |
Appears in Collections: | Publicaciones INER |
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