Please use this identifier to cite or link to this item:
http://sgc.anlis.gob.ar/handle/123456789/515| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Landreau, Fernando | en_US |
| dc.contributor.author | Galeano, Pablo | en_US |
| dc.contributor.author | Caltana, Laura R. | en_US |
| dc.contributor.author | Masciotra, Luis | en_US |
| dc.contributor.author | Chertcoff, Agustín | en_US |
| dc.contributor.author | Pontoriero, Andrea | en_US |
| dc.contributor.author | Baumeister, Elsa | en_US |
| dc.contributor.author | Amoroso, Marcela | en_US |
| dc.contributor.author | Brusco, Herminia A. | en_US |
| dc.contributor.author | Tous, Mónica | en_US |
| dc.contributor.author | Savy, Vilma L. | en_US |
| dc.contributor.author | Lores Arnaiz, María del Rosario | en_US |
| dc.contributor.author | Erausquin, Gabriel A. de | en_US |
| dc.date.accessioned | 2013-06-09T03:23:35Z | |
| dc.date.available | 2013-06-09T03:23:35Z | |
| dc.date.issued | 2012 | - |
| dc.identifier.uri | http://sgc.anlis.gob.ar/handle/123456789/515 | - |
| dc.identifier.uri | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051068 | - |
| dc.description | Influenza virus (InfV) infection during pregnancy is a known risk factor for neurodevelopment abnormalities in the offspring, including the risk of schizophrenia, and has been shown to result in an abnormal behavioral phenotype in mice. However, previous reports have concentrated on neuroadapted influenza strains, whereas increased schizophrenia risk is associated with common respiratory InfV. In addition, no specific mechanism has been proposed for the actions of maternal infection on the developing brain that could account for schizophrenia risk. We identified two common isolates from the community with antigenic configurations H3N2 and H1N1 and compared their effects on developing brain with a mouse modifiedstrain A/WSN/33 specifically on the developing of dopaminergic neurons. We found that H1N1 InfV have high affinity for dopaminergic neurons in vitro, leading to nuclear factor kappa B activation and apoptosis. Furthermore, prenatal infection of mothers with the same strains results in loss of dopaminergic neurons in the offspring, and in an abnormal behavioral phenotype. We propose that the well-known contribution of InfV to risk of schizophrenia during development may involve a similar specific mechanism and discuss evidence from the literature in relation to this hypothesis. | en_US |
| dc.language.iso | en_US | en_US |
| dc.relation.ispartof | Plos one | en_US |
| dc.relation.ispartofseries | Plos one; | - |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.source | PLOS ONE, 2012, 7(12), e51068. | en_US |
| dc.title | Effects of Two Commonly Found Strains of Influenza A Virus on Developing Dopaminergic Neurons, in Relation to the Pathophysiology of Schizophrenia | en_US |
| dc.type | Artículo | en_US |
| dc.identifier.doi | 10.1371/journal.pone.0051068 | - |
| item.openairetype | Artículo | - |
| item.grantfulltext | open | - |
| item.cerifentitytype | Publications | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
| item.fulltext | With Fulltext | - |
| item.languageiso639-1 | en_US | - |
| crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
| crisitem.author.dept | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
| crisitem.author.dept | Departamento de Virología | - |
| crisitem.author.dept | Servicio de Virosis Respiratoria | - |
| crisitem.author.dept | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
| crisitem.author.dept | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
| crisitem.author.dept | Departamento de Virología | - |
| crisitem.author.dept | Servicio de Virosis Respiratoria | - |
| crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
| crisitem.author.parentorg | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
| crisitem.author.parentorg | Departamento de Virología | - |
| crisitem.author.parentorg | Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS) | - |
| crisitem.author.parentorg | Instituto Nacional de Enfermedades Infecciosas (INEI) | - |
| crisitem.author.parentorg | Departamento de Virología | - |
| Appears in Collections: | Preproducción Publicaciones INEI Publicaciones INPB | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| PLOSONE,2012,7(12),e51068..pdf | 4.82 MB | Adobe PDF |  View/Open |
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