Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/447
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dc.contributor.authorChan, Paul K. S.
dc.contributor.authorLuk, Alfred C. S.
dc.contributor.authorPark, Jong-Sup
dc.contributor.authorSmith-McCune, Karen K.
dc.contributor.authorPalefsky, Joel M.
dc.contributor.authorKonno, Ryo
dc.contributor.authorGiovannelli, Lucia
dc.contributor.authorCoutlee, Francois
dc.contributor.authorHibbitts, Samantha
dc.contributor.authorChu, Tang-Yuan
dc.contributor.authorSettheetham-Ishida, Wannapa
dc.contributor.authorPicconi, María Alejandra
dc.contributor.authorFerrera, Annabelle
dc.contributor.authorDe Marco, Federico
dc.contributor.authorWoo, Yin-Ling
dc.contributor.authorRaiol, Taina
dc.contributor.authorPina-Sanchez, Patricia
dc.contributor.authorCheung, Jo L. K.
dc.contributor.authorBae, Jeong-Hoon
dc.contributor.authorChirenje, Mike Z.
dc.contributor.authorMagure, Tsitsi
dc.contributor.authorMoscicki, Anna-Barbara
dc.contributor.authorFiander, Alison N.
dc.contributor.authorDi Stefano, Rosa
dc.contributor.authorCheung, Tak-Hong
dc.contributor.authorYu, May M. Y.
dc.contributor.authorTsui, Stephen K. W.
dc.contributor.authorPim, David
dc.contributor.authorBanks, Lawrence
dc.date.accessioned2013-03-23T02:54:47Z
dc.date.available2013-03-23T02:54:47Z
dc.date.issued2011
dc.identifier.urihttp://sgc.anlis.gob.ar/handle/123456789/447
dc.descriptionBackground. Human papillomavirus type 58 (HPV-58) accounts for a much higher proportion of cervical cancers in East Asia than other types. A classification system of HPV-58, which is essential for molecular epidemiological study, is lacking. Methods and results. This study analyzed the sequences of 401 isolates collected from 15 countries and cities. The 268 unique concatenated E6-E7-E2-E5-L1-LCR sequences that comprised 57% of the whole HPV-58 genome showed 4 distinct clusters. L1 and LCR produced tree topologies that best resembled the concatenated sequences and thus are the most appropriate surrogate regions for lineage classification. Moreover, short fragments from L1 (nucleotides 6014–6539) and LCR (nucleotides 7257–7429 and 7540–52) were found to contain sequence signatures informative for lineage identification. Lineage A was the most prevalent lineage across all regions. Lineage C was more frequent in Africa than elsewhere, whereas lineage D was more prevalent in Africa than in Asia. Among lineage A variants, sublineage A2 dominated in Africa, the Americas, and Europe, but not in Asia. Sublineage A1, which represents the prototype that originated from a patient with cancer, was rare worldwide except in Asia. Conclusions. HPV-58 can be classified into 4 lineages that show some degree of ethnogeographic predilection in distribution. The evolutionary, epidemiological, and pathological characteristics of these lineages warrant further study.en_US
dc.rightsclosedAccessen_US
dc.sourceJournal of Infectious Diseases, 203(11), 1565-1573.en_US
dc.titleIdentification of Human Papillomavirus Type 58 Lineages and the Distribution Worldwideen_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.deptInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.deptDepartamento de Virología-
crisitem.author.deptServicio Virus Oncogénicos-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.parentorgInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.parentorgDepartamento de Virología-
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