Please use this identifier to cite or link to this item: http://sgc.anlis.gob.ar/handle/123456789/425
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dc.contributor.authorTonon, Sergio Andrés-
dc.contributor.authorBasiletti, Jorge-
dc.contributor.authorBadano, Inés-
dc.contributor.authorAlonio, Lidia V.-
dc.contributor.authorVilla, Luisa L.-
dc.contributor.authorTeyssie, Angelica R.-
dc.contributor.authorPicconi, María Alejandra-
dc.date.accessioned2012-11-27T13:05:38Z-
dc.date.available2012-11-27T13:05:38Z-
dc.date.issued2007-
dc.identifier.issn1201-9712-
dc.identifier.urihttp://sgc.anlis.gob.ar/handle/123456789/425-
dc.identifier.urihttp://download.journals.elsevierhealth.com/pdfs/journals/1201-9712/PIIS1201971206000488.pdf-
dc.descriptionObjective: To identify human papillomavirus type 16 (HPV16) E6 and L1 molecular variants infecting Guarani Indian women settled in Misiones, Argentina, a region with a high prevalence of cervical cancer. Some intratypic molecular variants of HPV16 have been associated with greater oncogenic risk, but their implication in the etiology of cervical cancer is still uncertain. Methods: Seventy HPV16 positive cervical samples from Guarani Indian women settled in two different areas of Misiones, Argentina, (34 from the northern area and 36 from the central area), were analyzed. Thirty-seven had normal cytology, 18 had a low-grade squamous intraepithelial lesion (LGSIL), and 15 a high-grade squamous intraepithelial lesion (HGSIL). HPV16 E6 and L1 molecular variants were identified by PCR, followed by dot blot hybridization with 23 and 12 biotinylated oligonucleotide probes, respectively. Results: The frequency of HPV16 variants over the Guarani population was 51% EP (European prototype), 32% E-350G, 9% Af1-a (African 1), 4% E-6862C, 3% Af2-a, and 1% AA-a (Asian-American). The distribution of variants was not homogeneous in the two areas under analysis, with the northern area being more diverse showing 74% of European variants, white the central area presented exclusively E variants. No statistically significant association was found between any particular variant and grade of cervical lesion. Conclusion: This study reports for the first time HPV16 E6 and L1 molecular variants infecting women from an aboriginal community inhabiting a rainforest region of South America. The presence of E class variants could be attributed primarily to contacts with the Spanish conquerors, and Af variants from African slaves introduced later in the South American continent.ES
dc.descriptionFil: Tonon, Sergio Andrés. Universidad Nacional de Misiones. Laboratorio de Biologia Molecular Aplicada; Argentina.ES
dc.descriptionFil: Basiletti, Jorge. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.ES
dc.descriptionFil: Badano, Inés. Universidad Nacional de Misiones. Laboratorio de Biologia Molecular Aplicada; Argentina.ES
dc.descriptionFil: Alonio, Lidia Virginia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.ES
dc.descriptionFil: Villa, Luisa Lina. Ludwig Institute for Cancer Research. Virology Department; Brasil.ES
dc.descriptionFil: Teyssie, Angelica Rita. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.ES
dc.descriptionFil: Picconi, María Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Virus Oncogénicos; Argentina.ES
dc.formatapplication/pdfES
dc.language.isoengen_US
dc.rights2008-01-31en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.sourceInternational Journal of Infectious Diseases, 2007, 11(1), 76-81.en_US
dc.subjectPapillomavirus Humano 16en_US
dc.subjectNeoplasias del Cuello Uterinoen_US
dc.subjectArgentinaen_US
dc.subjectMisionesen_US
dc.titleHuman papillomavirus type 16 molecular variants in Guarani Indian women from Misiones, Argentinaen_US
dc.typeArtículoes
dc.coverageARGen_US
dc.coverageMisionesen_US
anlis.essnrd1es
item.openairetypeArtículo-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.deptInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.deptDepartamento de Virología-
crisitem.author.deptServicio Virus Oncogénicos-
crisitem.author.deptMaestría en Microbiología Molecular UNSM-ANLIS-
crisitem.author.deptAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.deptInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.deptDepartamento de Virología-
crisitem.author.deptServicio Virus Oncogénicos-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.parentorgInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.parentorgDepartamento de Virología-
crisitem.author.parentorgCentro Nacional Red de Laboratorios (CNRL)-
crisitem.author.parentorgAdministración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS)-
crisitem.author.parentorgInstituto Nacional de Enfermedades Infecciosas (INEI)-
crisitem.author.parentorgDepartamento de Virología-
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